Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-T194,T207,T741-MASTL [nucleoplasm]
Stable Identifier
R-HSA-2430549
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-T194,207,741-MASTL, p-T194,207,741-GWL
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prophase (Homo sapiens)
MASTL Facilitates Mitotic Progression (Homo sapiens)
CDK1 phosphorylates MASTL (Homo sapiens)
p-T194,T207,T741-MASTL [nucleoplasm] (Homo sapiens)
MASTL (GWL) phosphorylates ARPP19 (Homo sapiens)
p-T194,T207,T741-MASTL [nucleoplasm] (Homo sapiens)
MASTL phosphorylates ENSA (Homo sapiens)
p-T194,T207,T741-MASTL [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96GX5 MASTL
Gene Names
MASTL, GW, GWL, THC2
Chain
chain:1-879
Reference Genes
BioGPS Gene:84930 MASTL
COSMIC (genes):MASTL MASTL
CTD Gene:84930 MASTL
dbSNP Gene:84930 MASTL
ENSEMBL:ENSG00000120539 MASTL
HGNC:19042 MASTL
KEGG:hsa:84930 MASTL
Monarch:84930 MASTL
NCBI Gene:84930 MASTL
OMIM:608221 MASTL
UCSC:Q96GX5 MASTL
Reference Transcript
RefSeq:NM_001172303.2 MASTL
RefSeq:NM_032844.4 MASTL
RefSeq:NM_001172304.2 MASTL
Other Identifiers
11723771_a_at
16703478
228468_PM_at
228468_at
3239996
3240014
3240015
3240016
3240017
3240018
3240019
3240020
3240021
3240023
3240024
3240025
3240026
3240028
3240029
3240030
3240031
76920_at
7926821
84930
A_14_P100358
A_14_P131142
A_23_P201988
A_24_P258051
GE83551
GO:0000086
GO:0000278
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005856
GO:0006468
GO:0006974
GO:0007147
GO:0007346
GO:0016301
GO:0016740
GO:0022414
GO:0032154
GO:0032515
GO:0035556
GO:0043226
GO:0051301
GO:0051721
GO:0051726
GO:0106310
GO:0140013
GO:0140096
HMNXSV003030765
Hs.14014.0.A1_3p_at
ILMN_1682336
ILMN_2135984
PH_hs_0023387
PH_hs_0040015
TC10000189.hg
Participates
as an output of
CDK1 phosphorylates MASTL (Homo sapiens)
Other forms of this molecule
MASTL [nucleoplasm]
Inferred To
phospho-gwl [nucleoplasm]
(Drosophila melanogaster)
phospho-MASTL [nucleoplasm]
(Bos taurus)
phospho-MASTL [nucleoplasm]
(Canis familiaris)
phospho-MASTL [nucleoplasm]
(Sus scrofa)
phospho-p-T194,T207,T741-MASTL [nucleoplasm]
(Danio rerio)
phospho-p-T194,T207,T741-MASTL [nucleoplasm]
(Gallus gallus)
phospho-p-T194,T207,T741-MASTL [nucleoplasm]
(Mus musculus)
phospho-p-T194,T207,T741-MASTL [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-p-T194,T207,T741-MASTL [nucleoplasm]
(Schizosaccharomyces pombe)
phospho-Mastl [nucleoplasm]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-threonine at 194
Coordinate
194
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 207
Coordinate
207
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 741
Coordinate
741
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_116233.2
,
NP_001165774.1
,
NP_001165775.1
Guide to Pharmacology - Targets
1514
ENSEMBL
ENSP00000343446
,
ENSP00000365107
,
ENST00000375940
,
ENST00000342386
,
ENSP00000365113
,
ENST00000375946
OpenTargets
ENSG00000120539
HPA
ENSG00000120539-MASTL
PRO
Q96GX5
Pharos - Targets
Q96GX5
GlyGen
Q96GX5
Orphanet
MASTL
HMDB Protein
HMDBP09496
PDB
5LOH
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text