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CES1 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-2429659
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Liver carboxylesterase 1 ecNumber3.1.1.1/ecNumber, EST1_HUMAN
Locations in the PathwayBrowser
Expand all
Drug ADME (Homo sapiens)
Aspirin ADME (Homo sapiens)
CES1,CES2 hydrolyze ASA- to ST (Homo sapiens)
CES1 trimer, CES2 [endoplasmic reticulum lumen] (Homo sapiens)
CES1 trimer [endoplasmic reticulum lumen] (Homo sapiens)
CES1 [endoplasmic reticulum lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
CES1 trimer.CES2 hydrolyse COCN to BEG (Homo sapiens)
CES1 trimer, CES2 [endoplasmic reticulum lumen] (Homo sapiens)
CES1 trimer [endoplasmic reticulum lumen] (Homo sapiens)
CES1 [endoplasmic reticulum lumen] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Metabolism of Angiotensinogen to Angiotensins (Homo sapiens)
CES1 trimer hydrolyses ACEI pro-drugs to ACEIs (Homo sapiens)
CES1 trimer [endoplasmic reticulum lumen] (Homo sapiens)
CES1 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23141 CES1
Gene Names
CES1, CES2, SES1
Chain
signal peptide:1-17, chain:18-567
Reference Genes
BioGPS Gene:1066 CES1
COSMIC (genes):CES1 CES1
COSMIC (genes):CES2 CES1
CTD Gene:1066 CES1
dbSNP Gene:1066 CES1
ENSEMBL:ENSG00000198848 CES1
HGNC:1863 CES1
KEGG:hsa:1066 CES1
Monarch:1066 CES1
NCBI Gene:1066 CES1
OMIM:114835 CES1
UCSC:P23141 CES1
Reference Transcript
RefSeq:NM_001266.4 CES1
RefSeq:NM_001025194.2 CES1
RefSeq:NM_001025195.2 CES1
Participates
as a component of
CES1 trimer [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
CES1 [lipid droplet]
Inferred To
cest-26 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
ges-1 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Dmel\CG6414 [endoplasmic reticulum lumen]
(Drosophila melanogaster)
cryS [endoplasmic reticulum lumen]
(Dictyostelium discoideum)
GH05741 [endoplasmic reticulum lumen]
(Drosophila melanogaster)
CES5A [endoplasmic reticulum lumen]
(Canis familiaris)
cest-13 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Jhe [endoplasmic reticulum lumen]
(Drosophila melanogaster)
ces3 [endoplasmic reticulum lumen]
(Danio rerio)
Ghost homologue of CES1 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
Jhedup [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Dmel\CG4382 [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Ces1d [endoplasmic reticulum lumen]
(Mus musculus)
Ces1d [endoplasmic reticulum lumen]
(Rattus norvegicus)
ces2a [endoplasmic reticulum lumen]
(Danio rerio)
cest-12 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
D2 [endoplasmic reticulum lumen]
(Dictyostelium discoideum)
clt [endoplasmic reticulum lumen]
(Drosophila melanogaster)
cest-17 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Homologues of CES1 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Homologues of CES1 [endoplasmic reticulum lumen]
(Danio rerio)
Homologues of CES1 [endoplasmic reticulum lumen]
(Dictyostelium discoideum)
Homologues of CES1 [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Homologues of CES1 [endoplasmic reticulum lumen]
(Sus scrofa)
CES1L1 [endoplasmic reticulum lumen]
(Gallus gallus)
LOC100736962 [endoplasmic reticulum lumen]
(Sus scrofa)
CES1 [endoplasmic reticulum lumen]
(Bos taurus)
CES1 [endoplasmic reticulum lumen]
(Dictyostelium discoideum)
CES1 [endoplasmic reticulum lumen]
(Sus scrofa)
cest-16 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
cest-24 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
cest-19 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Est17 [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Nrt [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001020366.1
,
NP_001257.4
,
NP_001020365.1
ZINC - World Drugs
EST1_HUMAN
Guide to Pharmacology - Targets
2592
OpenTargets
ENSG00000198848
ENSEMBL
ENST00000422046
,
ENST00000576783
,
ENSP00000355193
,
ENSG00000262243
,
ENSP00000460045
,
ENSP00000353720
,
ENST00000574513
,
ENSP00000390492
,
ENSG00000198848
,
ENST00000571922
,
ENST00000360526
,
ENST00000361503
,
ENSP00000461208
,
ENSP00000458586
ZINC - Substances
EST1_HUMAN
ZINC - Biogenic
EST1_HUMAN
ZINC target
P23141
PRO
P23141
GlyGen
P23141
PDB
3K9B
,
2H7C
,
2HRQ
,
8EOR
,
1MX1
,
2HRR
,
9KWL
,
2DR0
,
1YAJ
,
9KWM
,
4AB1
,
5A7F
,
1YAH
,
5A7H
,
5A7G
,
1YA4
,
1MX9
,
2DQZ
,
2DQY
,
1MX5
,
1YA8
ZINC - Investigational
EST1_HUMAN
ZINC - Metabolites
EST1_HUMAN
IntEnz
3.1.1.56
,
3.1.1.1
HPA
ENSG00000198848-CES1
GeneCards
CES1
Pharos - Targets
P23141
ZINC - Predictions - Purchasable
EST1_HUMAN
HMDB Protein
HMDBP00497
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