Reactome | IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4

IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4

Stable Identifier

R-HSA-2428930

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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General

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IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4

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IRS1 binds the NPEY-juxtamembrane motif of phosphorylated IGF1R (Craparo et al. 1995, He et al. 1995, Huang et al. 2001). IRS4 is also involved in signaling by IGF1R and is presumed to bind phosphorylated IGF1R in the same way as IRS1 (Qu et al. 1999, Cuevas et al. 2007). IRS1 and IRS4 are located at the plasma membrane (Karlsson et al. 2004, Fantin et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
17408801	Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation Cuevas, EP, Román, ID, Ramirez Rubio, S, Guijarro, LG, Escribano, O, Chiloeches, A, Fernández-Moreno, MD	J. Hepatol.	2007
7559478	Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains O'Neill, TJ, Gustafson, TA, He, W	J. Biol. Chem.	1995
9553137	Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells Lienhard, GE, Fantin, VR, Keller, SR, Sparling, JD, Lavan, BE, Slot, JW	J. Biol. Chem.	1998
7541045	Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor O'Neill, TJ, Gustafson, TA, Craparo, A	J. Biol. Chem.	1995
15182363	Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes. Cholesterol depletion blocks insulin signalling for metabolic and mitogenic control Ost, A, Karlsson, M, Danielsson, A, Thorn, H, Gustavsson, J, Nystrom, FH, Strålfors, P, Stenkula, KG	Eur. J. Biochem.	2004
10531310	Insulin receptor substrate-4 enhances insulin-like growth factor-I-induced cell proliferation Qu, BH, Karas, M, LeRoith, D, Koval, A	J. Biol. Chem.	1999
11557037	Effect of receptor phosphorylation on the binding between IRS-1 and IGF-1R as revealed by surface plasmon resonance biosensor Yang, M, Huang, M, Lai, WP, Wong, MS	FEBS Lett.	2001