IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4

Stable Identifier
R-HSA-2428930
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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IRS1 binds the NPEY-juxtamembrane motif of phosphorylated IGF1R (Craparo et al. 1995, He et al. 1995, Huang et al. 2001). IRS4 is also involved in signaling by IGF1R and is presumed to bind phosphorylated IGF1R in the same way as IRS1 (Qu et al. 1999, Cuevas et al. 2007). IRS1 and IRS4 are located at the plasma membrane (Karlsson et al. 2004, Fantin et al. 1998).

Literature References
PubMed ID Title Journal Year
7559478 Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains

He, W, O'Neill, TJ, Gustafson, TA

J. Biol. Chem. 1995
17408801 Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation

Cuevas, EP, Escribano, O, Chiloeches, A, Ramirez Rubio, S, Román, ID, Fernández-Moreno, MD, Guijarro, LG

J. Hepatol. 2007
9553137 Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells

Fantin, VR, Sparling, JD, Slot, JW, Keller, SR, Lienhard, GE, Lavan, BE

J. Biol. Chem. 1998
7541045 Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor

Craparo, A, O'Neill, TJ, Gustafson, TA

J. Biol. Chem. 1995
15182363 Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes. Cholesterol depletion blocks insulin signalling for metabolic and mitogenic control

Karlsson, M, Thorn, H, Danielsson, A, Stenkula, KG, Ost, A, Gustavsson, J, Nystrom, FH, Strålfors, P

Eur. J. Biochem. 2004
10531310 Insulin receptor substrate-4 enhances insulin-like growth factor-I-induced cell proliferation

Qu, BH, Karas, M, Koval, A, LeRoith, D

J. Biol. Chem. 1999
11557037 Effect of receptor phosphorylation on the binding between IRS-1 and IGF-1R as revealed by surface plasmon resonance biosensor

Huang, M, Lai, WP, Wong, MS, Yang, M

FEBS Lett. 2001
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