IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4

Stable Identifier
Homo sapiens
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Phosphorylated IGF1R phosphorylates IRS1 (Siemeister et al. 1995, Xu et al. 1995, Takahashi et al. 1997, Rakatzi et al. 2006), IRS2 (Kim et al. 1998, Kim et al. 2004), and IRS4 (Fantin et al.1998, Karas et al. 2001, Cuevas et al. 2007) on numerous tyrosine residues. IRS4 is phosphorylated by IGF1R in HEK cells but not in primary muscle cells (Fantin et al. 1998, Schreyer et al. 2003). The phosphotyrosine resideus create binding sites for downstream effectors such as GRB2:SOS and PI3K.

Literature References
PubMed ID Title Journal Year
17408801 Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation

Cuevas, EP, Román, ID, Ramirez Rubio, S, Guijarro, LG, Escribano, O, Chiloeches, A, Fernández-Moreno, MD

J. Hepatol. 2007
7876259 Recombinant human insulin receptor substrate-1 protein. Tyrosine phosphorylation and in vitro binding of insulin receptor kinase

al-Hasani, H, Krone, W, Müller-Wieland, D, Streicher, R, Kellner, S, Klein, HW, Siemeister, G

J. Biol. Chem. 1995
9832424 Differential regulation of insulin receptor substrate-2 and mitogen-activated protein kinase tyrosine phosphorylation by phosphatidylinositol 3-kinase inhibitors in SH-SY5Y human neuroblastoma cells

White, MF, Feldman, EL, Leventhal, PS, Kim, B

Endocrinology 1998
9003010 Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts

Yazaki, Y, Kadowaki, T, Takahashi, Y, Tobe, K, Fukushima, Y, Kadowaki, H, Katsumata, D, Akanuma, Y

Endocrinology 1997
14712218 Insulin-like growth factor-I signaling in human neuroblastoma cells

van Golen, CM, Feldman, EL, Kim, B

Oncogene 2004
11316748 The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II

Zick, Y, Karas, M, Koval, AP, LeRoith, D

Endocrinology 2001
9553137 Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells

Lienhard, GE, Fantin, VR, Keller, SR, Sparling, JD, Lavan, BE, Slot, JW

J. Biol. Chem. 1998
16754202 Differential phosphorylation of IRS-1 and IRS-2 by insulin and IGF-I receptors

Rakatzi, I, Siddle, K, Gromke, T, Eckel, J, Stosik, M

Arch. Physiol. Biochem. 2006
12639902 Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor

Rakatzi, I, Ledwig, D, Klöting, I, Schreyer, S, Eckel, J

Endocrinology 2003
8530377 Substrate specificities of the insulin and insulin-like growth factor 1 receptor tyrosine kinase catalytic domains

Bird, VG, Xu, B, Miller, WT

J. Biol. Chem. 1995
9852124 Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling

Feldman, EL, Cheng, HL, Margolis, B, Kim, B

J. Biol. Chem. 1998
Catalyst Activity

protein tyrosine kinase activity of IGF1,2:p-IGF1R:IRS1,2,4 [plasma membrane]

Orthologous Events
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