Interaction of DAP12 and IREM2

Stable Identifier
R-HSA-2426569
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Interaction of DAP12 and IREM2
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Immune receptor expressed by myeloid cells 2 (IREM-2), is a member of the Ig-superfamily expressed on myeloid cells. The extracellular region contains a single Ig variable and a positively charged amino acid lysine in its transmembrane region followed by a short cytoplasmic tail. IREM-2 associates with activating adaptor DAP12, through the transmembrane basic amino acid residue. This association induces NFAT transcriptional activity (Aguilar et al. 2004).
Literature References
PubMed ID Title Journal Year
15557162 Molecular characterization of a novel immune receptor restricted to the monocytic lineage

García-Montero, AC, Orfao, A, López-Botet, M, Alvarez-Errico, D, Aguilar, H, Sayós, J

J. Immunol. 2004
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Orthologous Events
Interaction of DAP12 and IREM2 (Canis familiaris)
Interaction of DAP12 and IREM2 (Mus musculus)
Interaction of DAP12 and IREM2 (Rattus norvegicus)
Authored
Garapati, P V  (2012-05-25)
Reviewed
Lanier, LL  (2012-08-09)
Created
Garapati, P V  (2012-08-06)
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