Interaction of DAP12 and IREM2

Stable Identifier
R-HSA-2426569
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Interaction of DAP12 and IREM2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Immune receptor expressed by myeloid cells 2 (IREM-2), is a member of the Ig-superfamily expressed on myeloid cells. The extracellular region contains a single Ig variable and a positively charged amino acid lysine in its transmembrane region followed by a short cytoplasmic tail. IREM-2 associates with activating adaptor DAP12, through the transmembrane basic amino acid residue. This association induces NFAT transcriptional activity (Aguilar et al. 2004).

Literature References
PubMed ID Title Journal Year
15557162 Molecular characterization of a novel immune receptor restricted to the monocytic lineage

Aguilar, H, Alvarez-Errico, D, García-Montero, AC, Orfao, A, Sayós, J, López-Botet, M

J. Immunol. 2004
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Interaction of DAP12 and IREM2 (Canis familiaris)
Interaction of DAP12 and IREM2 (Danio rerio)
Interaction of DAP12 and IREM2 (Mus musculus)
Interaction of DAP12 and IREM2 (Rattus norvegicus)
Authored
Garapati, P V  (2012-05-25)
Reviewed
Lanier, LL  (2012-08-09)
Created
Garapati, P V  (2012-08-06)