VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3

Stable Identifier
R-HSA-2426471
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
VTN binds integrins
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Integrin alphaVbeta3 is sometimes referred to as the 'vitronectin receptor'. Vitronectin interacts with integrins alphaVbeta1 (Marshall et al. 1995), alphaVbeta3 (Pytela et al. 1985, Boettiger et al. 2001), alphaVbeta5 (Panetti & McKeown-Longo 1993) and alpha2b beta3 (Pytela et al. 1986) through Arg-Gly-Asp (RGD) cell binding sequences.

Endothelial cells lining the microvascular wall form a semi-permeable barrier to the movement of blood components. The attachment of endothelial cells to the extracellular matrix (ECM) is largely mediated by transmembrane integrins which recognize short sequence motifs such as Arg-Gly-Asp (RGD) in many ECM proteins.

Integrin alpha5beta1 and alphaVbeta3 bind to the ECM proteins fibronectin and vitronectin respectively. Both are critical for the establishment and stabilization of endothelial monolayers (Cheng & Kramer 1989). Synthetic peptides that compete with ECM proteins for the integrins or antibodies directed against alpha5beta1 and alphaVbeta3 cause endothelial cell detachment (Hayman et al. 1985, Pierschbacher & Ruoslahti 1987).

Literature References
PubMed ID Title Journal Year
7685013 The alpha v beta 5 integrin receptor regulates receptor-mediated endocytosis of vitronectin

Panetti, TS, McKeown-Longo, PJ

J. Biol. Chem. 1993
2412224 A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin

Pytela, R, Pierschbacher, MD, Ruoslahti, E

Proc. Natl. Acad. Sci. U.S.A. 1985
7542669 Alpha v beta 1 is a receptor for vitronectin and fibrinogen, and acts with alpha 5 beta 1 to mediate spreading on fibronectin

Marshall, JF, Rutherford, DC, McCartney, AC, Mitjans, F, Goodman, SL, Hart, IR

J Cell Sci 1995
2420006 Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors

Pytela, R, Pierschbacher, MD, Ginsberg, MH, Plow, EF, Ruoslahti, E

Science 1986
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