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SREBP1A,1C binds the GPAM promoter
Stable Identifier
R-HSA-2426158
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SREBF1A,1C binds the GPAM promoter
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
SREBP1A,1C binds the GPAM promoter (Homo sapiens)
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SREBP1A (SREBF1A) or SREBP1C bind and transactivate promoter II of the GPAM gene (Harada et al. 2012). Promoter II is active in lipogenic tissues. As inferred from mouse, NF-Y also binds the GPAM promoter with SREBP1A/1C.
Literature References
PubMed ID
Title
Journal
Year
22634312
Identification and functional characterization of human glycerol-3-phosphate acyltransferase 1 gene promoters
Sakaue, H
,
Fujimoto, E
,
Nakaya, Y
,
Harada, N
,
Okuyama, M
Biochem. Biophys. Res. Commun.
2012
Participants
Input
GPAM gene [nucleoplasm]
(Homo sapiens)
NF-Y [nucleoplasm]
(Homo sapiens)
SREBP1A,1C dimer [nucleoplasm]
(Homo sapiens)
Output
SREBP1A,1C:NF-Y:GPAM gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Inferred From
Srebp1a/1c Binds the Gpam Promoter (Mus musculus)
Authored
May, B (2012-07-26)
Reviewed
Liang, G (2012-08-26)
Created
May, B (2012-07-27)
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