SREBP1A,1C binds the FASN promoter

Stable Identifier
R-HSA-2426148
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SREBF1A,1C binds the FASN promoter
ReviewStatus
5/5
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SREBP1A,1C binds the FASN promoter
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SREBP1A (SREBF1A) or SREBP1C, together with NF-Y and SP1, bind and transactivate the promoter of the FASN gene (Bennett et al. 1995, Pai et al. 1998, Xiong et al. 2000, Amemiya-Kudo et al. 2002, Shin et al. 2007, Choi et al. 2008, Rome et al. 2008). NF-Y is required for response to cholesterol (Xiong et al. 2000). SREBP1A activates FASN more strongly than does SREBP1C or SREBP2 (Pai et al. 1998, Amemiya-Kudo et al. 2002).
Literature References
PubMed ID Title Journal Year
18559965 Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle

Euthine, V, Lefai, E, Meugnier, E, Vidal, H, Debard, C, Rome, S, Rieusset, J, Lecomte, V

Physiol Genomics 2008
12177166 Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

Matsuzaka, T, Amemiya-Kudo, M, Ohashi, K, Yamada, N, Kimura, S, Tamura, Y, Yoshikawa, T, Yahagi, N, Harada, K, Iizuka, Y, Okazaki, H, Shimano, H, Ishibashi, S, Sato, R, Gotoda, T, Hasty, AH, Osuga, J

J Lipid Res 2002
7592729 Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways

Osborne, TF, Sanchez, HB, Lopez, JM, Bennett, MK

J Biol Chem 1995
10759542 Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites

Wakil, SJ, Chirala, SS, Xiong, S

Proc Natl Acad Sci U S A 2000
17449569 Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells

Shin, ES, Lee, HH, Park, HW, Lee, TR, Cho, SY, Lee, SJ

J Nutr 2007
9748295 Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins

Brown, MS, Pai, JT, Guryev, O, Goldstein, JL

J Biol Chem 1998
18682402 Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN)

Jeon, BN, Osborne, TF, Kim, YR, Kim, KS, Koh, DI, Park, H, Yoo, JY, Choi, WI, Lee, CE, Kim, YS, Hur, MW, Kim, MH

J Biol Chem 2008
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Output
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Authored
May, B  (2012-07-26)
Reviewed
Liang, G  (2012-08-26)
Created
May, B  (2012-07-27)
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