SREBP1A,1C binds the FASN promoter

Stable Identifier
Reaction [binding]
Homo sapiens
SREBF1A,1C binds the FASN promoter
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SREBP1A (SREBF1A) or SREBP1C, together with NF-Y and SP1, bind and transactivate the promoter of the FASN gene (Bennett et al. 1995, Pai et al. 1998, Xiong et al. 2000, Amemiya-Kudo et al. 2002, Shin et al. 2007, Choi et al. 2008, Rome et al. 2008). NF-Y is required for response to cholesterol (Xiong et al. 2000). SREBP1A activates FASN more strongly than does SREBP1C or SREBP2 (Pai et al. 1998, Amemiya-Kudo et al. 2002).
Literature References
PubMed ID Title Journal Year
18559965 Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle

Euthine, V, Lefai, E, Meugnier, E, Vidal, H, Debard, C, Rome, S, Rieusset, J, Lecomte, V

Physiol Genomics 2008
12177166 Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

Matsuzaka, T, Amemiya-Kudo, M, Ohashi, K, Yamada, N, Kimura, S, Tamura, Y, Yoshikawa, T, Yahagi, N, Harada, K, Iizuka, Y, Okazaki, H, Shimano, H, Ishibashi, S, Sato, R, Gotoda, T, Hasty, AH, Osuga, J

J Lipid Res 2002
7592729 Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways

Osborne, TF, Sanchez, HB, Lopez, JM, Bennett, MK

J Biol Chem 1995
10759542 Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites

Wakil, SJ, Chirala, SS, Xiong, S

Proc Natl Acad Sci U S A 2000
17449569 Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells

Shin, ES, Lee, HH, Park, HW, Lee, TR, Cho, SY, Lee, SJ

J Nutr 2007
9748295 Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins

Brown, MS, Pai, JT, Guryev, O, Goldstein, JL

J Biol Chem 1998
18682402 Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN)

Jeon, BN, Osborne, TF, Kim, YR, Kim, KS, Koh, DI, Park, H, Yoo, JY, Choi, WI, Lee, CE, Kim, YS, Hur, MW, Kim, MH

J Biol Chem 2008
Cite Us!