Phosphorylation of PLC-gamma by p-BTK/p-SYK

Stable Identifier
R-HSA-2424487
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Three tyrosine residues at positions 771, 783 and 1254 in PLCgamma1 have been identified as the sites of receptor tyrosine kinase phosphorylation. Of these Y783 and Y1254 are required for PLC-gamma1 activation.
In myeloid cells phosphorylation of the tyrosine residues of PLC-gamma1 is mediated by SYK and BTK kinases (Ormsby et al. 2010, Kim et al. 1994, Law et al. 1996, Watanabe et al. 2001).

Literature References
PubMed ID Title Journal Year
15184383 Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker

Humphries, LA, Dangelmaier, C, Sommer, K, Kipp, K, Kato, RM, Griffith, N, Bakman, I, Turk, CW, Daniel, JL, Rawlings, DJ

J. Biol. Chem. 2004
21659545 Btk is a positive regulator in the TREM-1/DAP12 signaling pathway

Ormsby, T, Schlecker, E, Ferdin, J, Tessarz, AS, Angelisová, P, Köprülü, AD, Borte, M, Warnatz, K, Schulze, I, Ellmeier, W, Horejsí, V, Cerwenka, A

Blood 2011
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-SYK/p-BTK [plasma membrane]
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Activity
Orthologous Events
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Created