Reactome | Phosphorylation of PLC-gamma by p-BTK/p-SYK

Phosphorylation of PLC-gamma by p-BTK/p-SYK

Stable Identifier

R-HSA-2424487

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Phosphorylation of PLC-gamma by p-BTK/p-SYK

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Three tyrosine residues at positions 771, 783 and 1254 in PLCgamma1 have been identified as the sites of receptor tyrosine kinase phosphorylation. Of these Y783 and Y1254 are required for PLC-gamma1 activation.
In myeloid cells phosphorylation of the tyrosine residues of PLC-gamma1 is mediated by SYK and BTK kinases (Ormsby et al. 2010, Kim et al. 1994, Law et al. 1996, Watanabe et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
21659545	Btk is a positive regulator in the TREM-1/DAP12 signaling pathway Ormsby, T, Schlecker, E, Ferdin, J, Tessarz, AS, Angelisová, P, Köprülü, AD, Borte, M, Warnatz, K, Schulze, I, Ellmeier, W, Horejsí, V, Cerwenka, A	Blood	2011
15184383	Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker Humphries, LA, Dangelmaier, C, Sommer, K, Kipp, K, Kato, RM, Griffith, N, Bakman, I, Turk, CW, Daniel, JL, Rawlings, DJ	J. Biol. Chem.	2004