Release of p-PLCG1

Stable Identifier
R-HSA-2424485
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Activated PLC-gamma1 disassociates from LAT. Membrane binding is crucial for PLC-gamma 1 activity. The PH-domain of PLC-gamma 1 binds to phosphatidylinositol 3,4,5-trisphosphate [PdtIns(3,4,5)P3], and is targeted to the membrane (Todderud et al. 1990, Wang & Wang. 2003, Kim et al. 2000). Activated PLCG1 then hydrolyses PIP2 to Inositol 1,4,5-triphosphate (IP3) and DAG

Literature References
PubMed ID Title Journal Year
2374928 Stimulation of phospholipase C-gamma 1 membrane association by epidermal growth factor

Todderud, G, Wahl, MI, Rhee, SG, Carpenter, G

Science 1990
11048639 The mechanism of phospholipase C-gamma1 regulation

Kim, MJ, Kim, E, Ryu, SH, Suh, PG

Exp Mol Med 2000
12911816 Regulation of EGF-induced phospholipase C-gamma1 translocation and activation by its SH2 and PH domains

Wang, Y, Wang, Z

Traffic 2003
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