p85 regulatory unit of PI3K binds p-6Y-SYK

Stable Identifier
R-HSA-2424482
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Phosphoinositide 3-kinases (PI3Ks) are one of the downstream effectors of activated SYK. The p85 alpha regulatory subunit of PI3K has been shown to interact with SYK phospho-tyrosine Y323. In DAP12 signaling SYK acts via the PI3K-dependent pathway to control NK cell-mediated cytotoxicity. SYK-coupled PI3K is rapidly activated and triggers a sequential activation of VAV2/VA3, RAC1, PAK1, MEK and ERK to mediate NK cell-mediated lysis (Jiang et al. 2002, Moon et al. 2005).

Literature References
PubMed ID Title Journal Year
11907067 Syk regulation of phosphoinositide 3-kinase-dependent NK cell function

Jiang, K, Zhong, B, Gilvary, DL, Corliss, BC, Vivier, E, Hong-Geller, E, Wei, S, Djeu, JY

J. Immunol. 2002
15536084 Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase

Moon, KD, Post, CB, Durden, DL, Zhou, Q, De, P, Harrison, ML, Geahlen, RL

J Biol Chem 2005
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