SOS mediated nucleotide exchange of RAS (SHC)

Stable Identifier
R-HSA-2424477
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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SOS mediated nucleotide exchange of RAS (SHC)
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GRB2-bound SOS promotes the formation of active GTP-bound RAS. This activates the mitogen-activated protein kinase (MAPK) cascade, leading to cell growth and differentiation.
Literature References
PubMed ID Title Journal Year
9690470 The structural basis of the activation of Ras by Sos

Boriack-Sjodin, PA, Margarit, SM, Kuriyan, J, Bar-Sagi, D

Nature 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane]

Physical Entity
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)
SOS mediated nucleotide exchange of RAS (SHC) (Canis familiaris)
SOS mediated nucleotide exchange of RAS (SHC) (Drosophila melanogaster)
SOS mediated nucleotide exchange of RAS (SHC) (Gallus gallus)
SOS mediated nucleotide exchange of RAS (SHC) (Mus musculus)
SOS mediated nucleotide exchange of RAS (SHC) (Rattus norvegicus)
SOS mediated nucleotide exchange of RAS (SHC) (Sus scrofa)
SOS mediated nucleotide exchange of RAS (SHC) (Xenopus tropicalis)
Authored
Garapati, P V  (2012-05-25)
Reviewed
Lanier, LL  (2012-08-09)
Created
Garapati, P V  (2012-07-23)
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