GRB2-bound SOS promotes the formation of active GTP-bound RAS. This activates the mitogen-activated protein kinase (MAPK) cascade, leading to cell growth and differentiation.
Boriack-Sjodin, PA, Margarit, SM, Kuriyan, J, Bar-Sagi, D
guanyl-nucleotide exchange factor activity of p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane]
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