Reactome | COMP binds collagen, fibronectin, aggrecan and matrilins

COMP binds collagen, fibronectin, aggrecan and matrilins

Stable Identifier

R-HSA-2424252

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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COMP binds collagen, fibronectin, aggrecan and matrilins

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Cartilage oligomeric matrix protein (COMP, thrombospondin-5) is a 524-kDa pentameric glycoprotein expressed primarily in cartilage, tendon, ligament and synovium. In adult cartilage, COMP is located primarily in the inter-territorial matrix between chondrocytes (Murphy et al. 1999). The mature protein is pentameric with each monomer linked to its neighbour by a disulphide bond, located at the amino terminus of the protein (Hedbom et al. 1992, Morgelin et al. 1992). COMP binds directly to collagen types I, II and IX (Rosenberg et al. 1998, Thur et al. 2001) at the fibril periphery. In addition it binds fibronectin (FN1) (Di Cesare et al. 2002), matrilins 1, 3 and 4 (Mann et al. 2004), and through the glycosaminoglycans heparan sulphate and chondroitin sulphate to aggrecan (Hauser et al. 1996, Chen et al. 2007).
Mutations in COMP lead to pseudoachondroplasia and multiple epiphyseal dysplasia (Jackson et al. 2012). COMP binding to FN1 and probably to other partners requires the presence of the divalent cations Ca2+, Mg2+ or Mn2+. Each COMP subunit binds approximately 10 calcium ions (Chen et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
12225811	Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin Fang, C, Chen, FS, Carlson, CS, Perris, R, Di Cesare, PE, Leslie, MP, Moergelin, M	Matrix Biol.	2002
15075323	Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias Wagener, R, Ozbek, S, Engel, J, Paulsson, M, Mann, HH	J. Biol. Chem.	2004
9685393	Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen Rosenberg, K, Mörgelin, M, Heinegård, D, Olsson, H	J. Biol. Chem.	1998
11084047	Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX Ala-Kokko, L, Rosenberg, K, Nitsche, DP, Maurer, P, Heinegård, D, Pihlajamaa, T, Paulsson, M, Thur, J	J. Biol. Chem.	2001
17588949	Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan Herndon, ME, Hecht, JT, Chen, FH, Tuan, RS, Lawler, J, Patel, N	J. Biol. Chem.	2007
8943283	Interaction of cartilage matrix protein with aggrecan. Increased covalent cross-linking with tissue maturation Heinegârd, D, Mörgelin, M, Hauser, N, Paulsson, M	J. Biol. Chem.	1996