COMP binds collagen, fibronectin, aggrecan and matrilins

Stable Identifier
R-HSA-2424252
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Cartilage oligomeric matrix protein (COMP, thrombospondin-5) is a 524-kDa pentameric glycoprotein expressed primarily in cartilage, tendon, ligament and synovium. In adult cartilage, COMP is located primarily in the inter-territorial matrix between chondrocytes (Murphy et al. 1999). The mature protein is pentameric with each monomer linked to its neighbour by a disulphide bond, located at the amino terminus of the protein (Hedbom et al. 1992, Morgelin et al. 1992). COMP binds directly to collagen types I, II and IX (Rosenberg et al. 1998, Thur et al. 2001) at the fibril periphery. In addition it binds fibronectin (FN1) (Di Cesare et al. 2002), matrilins 1, 3 and 4 (Mann et al. 2004), and through the glycosaminoglycans heparan sulphate and chondroitin sulphate to aggrecan (Hauser et al. 1996, Chen et al. 2007).
Mutations in COMP lead to pseudoachondroplasia and multiple epiphyseal dysplasia (Jackson et al. 2012). COMP binding to FN1 and probably to other partners requires the presence of the divalent cations Ca2+, Mg2+ or Mn2+. Each COMP subunit binds approximately 10 calcium ions (Chen et al. 2000).

Literature References
PubMed ID Title Journal Year
15075323 Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias

Mann, HH, Ozbek, S, Engel, J, Paulsson, M, Wagener, R

J. Biol. Chem. 2004
12225811 Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin

Di Cesare, PE, Chen, FS, Moergelin, M, Carlson, CS, Leslie, MP, Perris, R, Fang, C

Matrix Biol. 2002
9685393 Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen

Rosenberg, K, Olsson, H, Mörgelin, M, Heinegård, D

J. Biol. Chem. 1998
11084047 Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX

Thur, J, Rosenberg, K, Nitsche, DP, Pihlajamaa, T, Ala-Kokko, L, Heinegård, D, Paulsson, M, Maurer, P

J. Biol. Chem. 2001
17588949 Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan

Chen, FH, Herndon, ME, Patel, N, Hecht, JT, Tuan, RS, Lawler, J

J. Biol. Chem. 2007
8943283 Interaction of cartilage matrix protein with aggrecan. Increased covalent cross-linking with tissue maturation

Hauser, N, Paulsson, M, Heinegârd, D, Mörgelin, M

J. Biol. Chem. 1996
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