Reactome | CR:atREs binds apoE and HSPG

CR:atREs binds apoE and HSPG

Stable Identifier

R-HSA-2423785

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

CR remnants bind to apoE, enhanced by HSPG, in preparation for internalisation

ReviewStatus

5/5

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When the low-density lipoprotein receptor (LDLR) is missing, saturated or inhibited, chylomicron remnants (CRs) containing all-trans-retinyl esters (atREs) bind apolioprotein E (apoE). ApoE, secreted by hepatocytes, acts as a high-affinity ligand for the LDL-related receptor protein (LRP) family. CR:atREs:apoE then binds to cell-surface heparan sulfate proteoglycan (HSPG), abundant in the space of Disse. HSPG/apoE binding plays a critical role in the capture of CR:atREs, ready for internalization via LRPs (Futamura et al. 2005, Yamauchi et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
15583000	Two-step mechanism of binding of apolipoprotein E to heparin: implications for the kinetics of apolipoprotein E-heparan sulfate proteoglycan complex formation on cell surfaces Futamura, M, Saito, H, Phillips, MC, Dhanasekaran, P, Lund-Katz, S, Handa, T	J. Biol. Chem.	2005
18507396	Role of the N- and C-terminal domains in binding of apolipoprotein E isoforms to heparan sulfate and dermatan sulfate: a surface plasmon resonance study Yamauchi, Y, Saito, H, Deguchi, N, Phillips, MC, Takagi, C, Nakano, M, Dhanasekaran, P, Tanaka, M, Lund-Katz, S, Handa, T	Biochemistry	2008