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p-Y204-MAPK3-3 [cytosol]
Stable Identifier
R-HSA-2422448
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-Y204-ERK1-3, p-Y204-ERK1b
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Golgi Cisternae Pericentriolar Stack Reorganization (Homo sapiens)
MAPK3-3 or MAPK1 phosphorylate GORASP2 (Homo sapiens)
p-Y204-MAPK3-3/p-T185,Y187-MAPK1 homodimer [cytosol] (Homo sapiens)
p-Y204-MAPK3-3 homodimer [cytosol] (Homo sapiens)
p-Y204-MAPK3-3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P27361-3 MAPK3
Gene Names
MAPK3, ERK1, PRKM3
Other Identifiers
1000_at
11717543_x_at
16825661
212046_3p_x_at
212046_PM_x_at
212046_x_at
3687489
3687490
3687491
3687493
3687495
3687496
3687497
3687498
3687499
3687500
3687501
3687502
3687503
3687505
3687508
3687509
3687510
3687511
3687512
5595
8000811
A_23_P37910
GE79221
GO:0000165
GO:0001784
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0005515
GO:0005524
GO:0005634
GO:0005635
GO:0005654
GO:0005737
GO:0005739
GO:0005768
GO:0005769
GO:0005770
GO:0005788
GO:0005794
GO:0005829
GO:0005856
GO:0005886
GO:0005901
GO:0005925
GO:0006351
GO:0006355
GO:0006468
GO:0006914
GO:0006915
GO:0006974
GO:0008286
GO:0009887
GO:0010759
GO:0012501
GO:0014032
GO:0014044
GO:0016020
GO:0016192
GO:0016310
GO:0016740
GO:0019233
GO:0019902
GO:0030154
GO:0030278
GO:0030509
GO:0030641
GO:0030878
GO:0031143
GO:0031281
GO:0031410
GO:0031663
GO:0032206
GO:0032496
GO:0032872
GO:0034198
GO:0034614
GO:0035556
GO:0038083
GO:0038133
GO:0042473
GO:0042552
GO:0042770
GO:0042802
GO:0043226
GO:0043330
GO:0045944
GO:0048009
GO:0048538
GO:0048856
GO:0050804
GO:0050877
GO:0051216
GO:0051403
GO:0051493
GO:0060020
GO:0060324
GO:0060425
GO:0060440
GO:0061308
GO:0070161
GO:0070371
GO:0070374
GO:0070498
GO:0070849
GO:0071260
GO:0071276
GO:0071356
GO:0072584
GO:0090170
GO:0098792
GO:0098978
GO:0106310
GO:0120041
GO:0140096
GO:0140297
GO:1904262
GO:1904417
GO:2000641
HMNXSV003008674
HMNXSV003058073
Hs.861.0.S1_3p_at
Hs.861.0.S1_3p_x_at
ILMN_1667260
ILMN_2402341
PH_hs_0000106
TC16001021.hg
X60188_at
Participates
as a component of
p-Y204-MAPK3-3 homodimer [cytosol] (Homo sapiens)
Inferred To
phospho-p-Y204-MAPK3-3 [cytosol]
(Bos taurus)
phospho-p-Y204-MAPK3-3 [cytosol]
(Caenorhabditis elegans)
phospho-p-Y204-MAPK3-3 [cytosol]
(Danio rerio)
phospho-p-Y204-MAPK3-3 [cytosol]
(Drosophila melanogaster)
phospho-p-Y204-MAPK3-3 [cytosol]
(Mus musculus)
phospho-p-Y204-MAPK3-3 [cytosol]
(Rattus norvegicus)
phospho-p-Y204-MAPK3-3 [cytosol]
(Sus scrofa)
phospho-MAPK3 [cytosol]
(Canis familiaris)
Modified Residues
Name
O4'-phospho-L-tyrosine at 204
Coordinate
204
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_002737.2
,
NP_001035145.1
,
NP_001103361.1
Guide to Pharmacology - Targets
1494
ENSEMBL
ENST00000395199
,
ENST00000263025
,
ENSG00000102882
,
ENST00000322266
,
ENST00000395202
,
ENSP00000263025
,
ENSP00000327293
,
ENSP00000378628
,
ENSP00000378625
OpenTargets
ENSG00000102882
ZINC - FDA approved
MK03_HUMAN
ZINC - Substances
MK03_HUMAN
ZINC - Biogenic
MK03_HUMAN
ZINC target
P27361
PRO
P27361
PDB
4QTB
,
2ZOQ
,
6GES
ZINC - Investigational
MK03_HUMAN
ZINC - Metabolites
MK03_HUMAN
GeneCards
MAPK3
HPA
ENSG00000102882-MAPK3
Pharos - Targets
P27361
ZINC - Predictions - Purchasable
MK03_HUMAN
HMDB Protein
HMDBP01263
Interactors (40)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49366 DHPS
1
DHPS [cytosol]
(R-HSA-204630)
0.919
10
UniProt:P28482 MAPK1
18
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
MAPK1 [cytosol]
(R-HSA-59282)
MAPK1 [nucleoplasm]
(R-HSA-199960)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
0.774
8
UniProt:Q16828 DUSP6
2
DUSP6 [cytosol]
(R-HSA-5675343)
DUSP6 [nucleoplasm]
(R-HSA-2871619)
0.744
5
UniProt:Q15121 PEA15
1
PEA15 [cytosol]
(R-HSA-5675204)
0.743
5
UniProt:Q15349 RPS6KA2
7
p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm]
(R-HSA-444290)
p-T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(R-HSA-9619984)
p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
(R-HSA-9619869)
p-T356,S360,T570-RPS6KA2 [cytosol]
(R-HSA-9619955)
RPS6KA2 [cytosol]
(R-HSA-444252)
p-4S,T356,T570-RPS6KA2 [nucleoplasm]
(R-HSA-199871)
RPS6KA2 [nucleoplasm]
(R-HSA-199861)
0.706
5
UniProt:P28562 DUSP1
1
DUSP1 [nucleoplasm]
(R-HSA-203796)
0.706
3
UniProt:Q12913 PTPRJ
2
PTPRJ [plasma membrane]
(R-HSA-6785269)
PTPRJ [specific granule membrane]
(R-HSA-6799570)
0.697
5
UniProt:Q16539 MAPK14
7
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
MAPK14 [cytosol]
(R-HSA-428933)
MAPK14 [nucleoplasm]
(R-HSA-446223)
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
0.691
5
UniProt:Q62132 PTPRR
0.667
3
UniProt:P54829 PTPN5
1
PTPN5 [nucleoplasm]
(R-HSA-9008908)
0.643
3
UniProt:P23467 PTPRB
3
PTPRB [tertiary granule membrane]
(R-HSA-6801032)
PTPRB [plasma membrane]
(R-HSA-437247)
PTPRB [specific granule membrane]
(R-HSA-6799638)
0.623
2
UniProt:P27361 MAPK3
6
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
MAPK3 [cytosol]
(R-HSA-59284)
MAPK3 [nucleoplasm]
(R-HSA-73724)
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
0.623
2
UniProt:P53355 DAPK1
1
DAPK1 [cytosol]
(R-HSA-418262)
0.618
5
UniProt:P51812 RPS6KA3
7
p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm]
(R-HSA-444286)
p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol]
(R-HSA-9619989)
p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol]
(R-HSA-9619872)
p-T365,S369,T577-RPS6KA3 [cytosol]
(R-HSA-9619959)
RPS6KA3 [cytosol]
(R-HSA-444250)
p-4S,T231,T365-RPS6KA3 [nucleoplasm]
(R-HSA-199830)
RPS6KA3 [nucleoplasm]
(R-HSA-199869)
0.615
5
UniProt:Q99956 DUSP9
1
DUSP9 [cytosol]
(R-HSA-5675351)
0.615
3
UniProt:P19419 ELK1
2
ELK1 [nucleoplasm]
(R-HSA-3009346)
p-4S,T336-ELK1 [nucleoplasm]
(R-HSA-3009350)
0.571
2
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.558
2
UniProt:Q9EPI6 NSMF
0.558
2
UniProt:Q9ULW8 PADI3
2
PADI3 [cytosol]
(R-HSA-1183173)
PADI3 [nucleoplasm]
(R-HSA-6793444)
0.556
3
UniProt:P13051-2 UNG
0.556
3
UniProt:Q6GQQ9-2 Q6GQQ92
0.556
3
UniProt:Q9HCU0 CD248
0.556
3
UniProt:Q49AJ0-4 Q49AJ04
0.556
3
UniProt:Q8N490 PNKD
0.556
4
UniProt:Q96HT8 MR1L1
0.556
3
UniProt:Q96NJ5 KLH32
0.556
3
UniProt:Q9UK32 RPS6KA6
5
p-S232,T368,S372,S389,T581,S742-RPS6KA6 [nucleoplasm]
(R-HSA-444293)
p-T368,S372,S389,T581,S742-RPS6KA6 [cytosol]
(R-HSA-9619985)
p-S232,T368,S372,S389,T581,S742-RPS6KA6 [cytosol]
(R-HSA-9619870)
p-T368,S372,T581-RPS6KA6 [cytosol]
(R-HSA-9619958)
RPS6KA6 [cytosol]
(R-HSA-444266)
0.547
2
UniProt:Q9H8X9 ZDHHC11
1
ZDHHC11 [Golgi membrane]
(R-HSA-9774147)
0.527
2
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.527
3
UniProt:Q15418 RPS6KA1
7
p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm]
(R-HSA-444292)
p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619993)
p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619871)
p-T359,S363,T573-RPS6KA1 [cytosol]
(R-HSA-9619957)
RPS6KA1 [cytosol]
(R-HSA-444256)
p-4S,T359,T573-RPS6KA1 [nucleoplasm]
(R-HSA-199829)
RPS6KA1 [nucleoplasm]
(R-HSA-199860)
0.527
2
UniProt:O75386 TULP3
1
TULP3 [cilium]
(R-HSA-5610445)
0.527
2
UniProt:Q8WVK2 SNRNP27
1
SNRNP27 [nucleoplasm]
(R-HSA-6806778)
0.527
2
UniProt:Q5VWX1 KHDRBS2
2
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
0.527
2
UniProt:Q13227 GPS2
1
GPS2 [nucleoplasm]
(R-HSA-351642)
0.527
2
UniProt:Q9H4H8 FAM83D
1
FAM83D [cytosol]
(R-HSA-9852722)
0.527
3
UniProt:O94822 LTN1
1
LTN1 [cytosol]
(R-HSA-5688967)
0.527
2
UniProt:Q7Z7G2 CPLX4
0.527
2
UniProt:P50548 ERF
3
p-T526-ERF [nucleoplasm]
(R-HSA-3209166)
p-T526-ERF [cytosol]
(R-HSA-3209167)
ERF [nucleoplasm]
(R-HSA-2534321)
0.527
2
UniProt:Q92576 PHF3
0.527
2
UniProt:Q02750 MAP2K1
20
MAP2K1(9-393) [cytosol]
(R-HSA-5211353)
MAP2K1(2-8) [cytosol]
(R-HSA-5211342)
MAP2K1 F53S [cytosol]
(R-HSA-9652034)
MAP2K1 D67N [cytosol]
(R-HSA-9652016)
p-S218,S222-MAP2K1 [cytosol]
(R-HSA-109837)
MAP2K1 [cytosol]
(R-HSA-59502)
p-S218,S222,T286,T292-MAP2K1 [cytosol]
(R-HSA-112339)
p-T286,T292-MAP2K1 [cytosol]
(R-HSA-112374)
p-S,218, S222,T292 MAP2K1 [cytosol]
(R-HSA-5674490)
MAP2K1 F53C [cytosol]
(R-HSA-9652028)
MAP2K1 P124Q [cytosol]
(R-HSA-9652058)
MAP2K1 L42_K57del [cytosol]
(R-HSA-9652026)
MAP2K1 F53Y [cytosol]
(R-HSA-9652041)
MAP2K1 P124L [cytosol]
(R-HSA-9652056)
MAP2K1 G128D [cytosol]
(R-HSA-9652043)
MAP2K1 D67Y [cytosol]
(R-HSA-9652019)
MAP2K1 F53V [cytosol]
(R-HSA-9652038)
MAP2K1 K57T [cytosol]
(R-HSA-9652052)
MAP2K1 K57N [cytosol]
(R-HSA-9652050)
MAP2K1 F53L [cytosol]
(R-HSA-9652031)
0.499
2
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