Me2Se is methylated to Me3Se+ by INMT

Stable Identifier
R-HSA-2408554
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Me2Se is methylated to Me3Se+ by INMT
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Indolethylamine N-methyltransferase (INMT) is involved in the methylation of dimethyl selenide (Me2Se) into trimethylselenonium (Me3Se+) in tandem with S-adenosylmethionine (AdoMet) transforming into S-adenosylhomocysteine (AdoHcy). This reaction is inferred from the event in mouse (Mozier et al. 1988).
Literature References
PubMed ID Title Journal Year
3350800 S-adenosyl-L-methionine:thioether S-methyltransferase, a new enzyme in sulfur and selenium metabolism

McConnell, KP, Mozier, NM, Hoffman, JL

J. Biol. Chem. 1988
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Catalyst Activity

dimethyl selenide methyltransferase activity of INMT [cytosol]

Physical Entity
INMT [cytosol] (Homo sapiens)
Activity
dimethyl selenide methyltransferase activity (GO:0098615)
Inferred From
Me2Se is methylated to Me3Se+ by Inmt (Mus musculus)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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