AdoSeMet is converted to AdeSeHCys by MetTrans(1)

Stable Identifier
R-HSA-2408544
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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AdoSeMet is converted to AdeSeHCys by MetTrans(1)
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A set of methyltransferases (MetTrans(1)) consisting of the proteins histamine-N-methyltransferase (HNMT), glycine-N-methyltransferase (GNMT), and nicotinamide-N-methyltransferase (NNMT) remove a methyl group from adenosylselenomethionine (AdoSeMet) to leave adenosylselenohomocysteine (AdeSeHCys). This reaction is inferred from the event in rat involving the set of methyltransferases (MetTrans(2)) consisting of the proteins histamine-N-methyltransferase (Hnmt), glycine-N-methyltransferase (Gnmt), and nicotinamide-N-methyltransferase (Nnmt) (Kajander et al. 1991).

Literature References
PubMed ID Title Journal Year
1711890 Metabolism, cellular actions, and cytotoxicity of selenomethionine in cultured cells

Kajander, EO, Harvima, RJ, Eloranta, TO, Martikainen, H, Kantola, M, Kärenlampi, SO, Akerman, KK

Biol Trace Elem Res 1991
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
selenol Se-methyltransferase activity of MetTrans(1) [cytosol]
Physical Entity
MetTrans(1) [cytosol]
Activity
selenol Se-methyltransferase activity (0098603)
Inferred From
AdoSeMet is converted to AdeSeHCys by MetTrans(2) (Rattus norvegicus)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)