AdoSeMet is converted to AdeSeHCys by MetTrans(1)

Stable Identifier
R-HSA-2408544
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AdoSeMet is converted to AdeSeHCys by MetTrans(1)
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A set of methyltransferases (MetTrans(1)) consisting of the proteins histamine-N-methyltransferase (HNMT), glycine-N-methyltransferase (GNMT), and nicotinamide-N-methyltransferase (NNMT) remove a methyl group from adenosylselenomethionine (AdoSeMet) to leave adenosylselenohomocysteine (AdeSeHCys). This reaction is inferred from the event in rat involving the set of methyltransferases (MetTrans(2)) consisting of the proteins histamine-N-methyltransferase (Hnmt), glycine-N-methyltransferase (Gnmt), and nicotinamide-N-methyltransferase (Nnmt) (Kajander et al. 1991).

Literature References
PubMed ID Title Journal Year
1711890 Metabolism, cellular actions, and cytotoxicity of selenomethionine in cultured cells

Akerman, KK, Kärenlampi, SO, Martikainen, H, Harvima, RJ, Kajander, EO, Kantola, M, Eloranta, TO

Biol Trace Elem Res 1991
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Output
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as an event of
Catalyst Activity

selenol Se-methyltransferase activity of MetTrans(1) [cytosol]

Physical Entity
MetTrans(1) [cytosol] (Homo sapiens)
Activity
selenol Se-methyltransferase activity (GO:0098603)
Inferred From
AdoSeMet is converted to AdeSeHCys by MetTrans(2) (Rattus norvegicus)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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