MeSeH is methylated to Me2Se by MeSeH methyltransferase

Stable Identifier
R-HSA-2408541
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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MeSeH is methylated to Me2Se by MeSeH methyltransferase
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A yet to be identified enzyme with methylselenol methyltransferase (MeSeHMT) activity is involved in the methylation of methylselenol aka methaneselenol (MeSeH) into dimethyl selenide (Me2Se) in tandem with S-adenosylmethionine (AdoMet) transforming into S-adenosylhomocysteine (AdoHcy). This reaction is inferred from the event in rat (Ohta and Suzuki 2008, Hsieh and Ganther 1977).
Literature References
PubMed ID Title Journal Year
17988700 Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium

Suzuki, KT, Ohta, Y

Toxicol. Appl. Pharmacol. 2008
14705 Biosynthesis of dimethyl selenide from sodium selenite in rat liver and kidney cell-free systems

Ganther, HE, Hsieh, HS

Biochim. Biophys. Acta 1977
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Catalyst Activity

methaneselenol methyltransferase activity of MeSeHMT [cytosol]

Physical Entity
MeSeHMT [cytosol] (Homo sapiens)
Activity
methaneselenol methyltransferase activity (GO:0098613)
Inferred From
MeSeH is methylated to Me2Se by MeSeH methyltransferase (Rattus norvegicus)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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