Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH

Stable Identifier
R-HSA-2408537
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH
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Excess selenomethionine (SeMet) undergoes an alpha,gamma-elimination reaction by cystathionine gamma-lyase (CTH) to produce methylselenol aka methaneselenol (MeSeH), ammonia, and 2-oxobutanoic acid. This reaction is inferred from the event in mouse involving the protein cystathionine gamma-lyase (Cth) (Okuno et al. 2001, Okuno et al. 2005, Okuno et al. 2006).
Literature References
PubMed ID Title Journal Year
11578145 Contribution of enzymic alpha, gamma-elimination reaction in detoxification pathway of selenomethionine in mouse liver

Okuno, T, Kubota, T, Kuroda, T, Ueno, H, Nakamuro, K

Toxicol. Appl. Pharmacol. 2001
16444005 Cystathionine gamma-lyase contributes to selenomethionine detoxification and cytosolic glutathione peroxidase biosynthesis in mouse liver

Okuno, T, Ueno, H, Nakamuro, K

Biol Trace Elem Res 2006
16037612 Purification and characterization of mouse hepatic enzyme that converts selenomethionine to methylselenol by its alpha,gamma-elimination

Okuno, T, Motobayashi, S, Ueno, H, Nakamuro, K

Biol Trace Elem Res 2005
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Output
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as an event of
Catalyst Activity

selenomethionine gamma-lyase activity of PXLP-K212-CTH tetramer [cytosol]

Physical Entity
PXLP-K212-CTH tetramer [cytosol] (Homo sapiens)
Activity
selenomethionine gamma-lyase activity (GO:0098600)
Inferred From
Excess SeMet is cleaved into MeSeH by PXLP-K211-Cth (Mus musculus)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Hill, DP  (2025-02-25)
Created
Williams, MG  (2012-07-17)
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