MeSeH is hydrolysed to H2Se by methylselenol demethylase

Stable Identifier
R-HSA-2408530
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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MeSeH is hydrolysed to H2Se by methylselenol demethylase
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A yet to be identified enzyme with methylselenol demethylase (MSDM) activity is involved in the hydrolysis of methylselenol aka methaneselenol (MeSeH) into hydrogen selenide (H2Se) and methanol. This reaction is inferred from the event in rat (Suzuki et al. 2007, Ohta and Suzuki 2008).
Literature References
PubMed ID Title Journal Year
17988700 Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium

Suzuki, KT, Ohta, Y

Toxicol. Appl. Pharmacol. 2008
17451884 Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide

Suzuki, KT, Suzuki, N, Kurasaki, K

Biochim. Biophys. Acta 2007
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Catalyst Activity

methylselenol demethylase activity of MSDM [cytosol]

Physical Entity
MSDM [cytosol] (Homo sapiens)
Activity
methylselenol demethylase activity (GO:0098608)
Inferred From
MeSeH is hydrolysed to H2Se by methylselenol demethylase (Rattus norvegicus)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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