Reactome | Sec is reduced to H2Se by PXLP-K259-SCLY dimer

Sec is reduced to H2Se by PXLP-K259-SCLY dimer

Stable Identifier

R-HSA-2408524

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AH2 + L-selenocysteine => A + H(+) + hydrogenselenide + L-alanine

ReviewStatus

5/5

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Sec is reduced to H2Se by PXLP-K259-SCLY dimer

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Selenocysteine lyase (SCLY) homodimer is involved in the reduction of selenocysteine (Sec) to hydrogen selenide (H2Se) and alanine (Ala) (Daher and Van Lente 1992).

Literature References

PubMed ID	Title	Journal	Year
1483038	Characterization of selenocysteine lyase in human tissues and its relationship to tissue selenium concentrations Daher, R, Van Lente, F	J Trace Elem Electrolytes Health Dis	1992
20164179	Reaction mechanism and molecular basis for selenium/sulfur discrimination of selenocysteine lyase Omi, R, Kurokawa, S, Mihara, H, Hayashi, H, Goto, M, Miyahara, I, Kurihara, T, Hirotsu, K, Esaki, N	J. Biol. Chem.	2010