Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK

Stable Identifier
R-HSA-2408507
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK
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L-seryl-tRNA(Sec) kinase (PSTK) phosphorylates the serylated transfer RNA (tRNA) for Sec (Ser-tRNASec) to form Sep-tRNASec in the presence of ATP and Mg2+. PSTK exhibits a strict selectivity for Ser-tRNASec. It does not phosphorylate free Ser or Ser attached to its cognate tRNASer. This reaction involving PSTK is inferred from the equivalent reaction in mouse.
Literature References
PubMed ID Title Journal Year
15317934 Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase

Carlson, BA, Kryukov, GV, Berry, MJ, Hatfield, DL, Rao, M, Gladyshev, VN, Xu, XM

Proc. Natl. Acad. Sci. U.S.A. 2004
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Catalyst Activity

seryl-selenocysteinyl-tRNA kinase activity of PSTK:Mg2+ [cytosol]

Physical Entity
PSTK:Mg2+ [cytosol] (Homo sapiens)
Activity
seryl-selenocysteinyl-tRNA kinase activity (GO:0098620)
Inferred From
Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by Pstk (Mus musculus)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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