Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK

Stable Identifier
R-HSA-2408507
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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L-seryl-tRNA(Sec) kinase (PSTK) phosphorylates the serylated transfer RNA (tRNA) for Sec (Ser-tRNASec) to form Sep-tRNASec in the presence of ATP and Mg2+. PSTK exhibits a strict selectivity for Ser-tRNASec. It does not phosphorylate free Ser or Ser attached to its cognate tRNASer. This reaction involving PSTK is inferred from the equivalent reaction in mouse.

Literature References
PubMed ID Title Journal Year
15317934 Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase

Carlson, BA, Xu, XM, Kryukov, GV, Rao, M, Berry, MJ, Gladyshev, VN, Hatfield, DL

Proc. Natl. Acad. Sci. U.S.A. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
seryl-selenocysteinyl-tRNA kinase activity of PSTK:Mg2+ [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created