IGF1,2 binds IGF1R

Stable Identifier
R-HSA-2404200
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IGF1,2 binds IGF1R
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Either IGF1 (IGF-I) or IGF2 (IGF-II) can bind the type 1 insulin-like growth factor receptor (IGF1R) (Casella et al. 1986, LeBon et al. 1986, Maly and Luthi 1986, Cacieri et al. 1988, Steele-Perkins et al. 1988, Burgisser et al. 1991, Germain-Lee et al. 1992, Keyhanfar et al. 2007, Alvino et al. 2009, Alvino et al. 2011). IGF1R has similar affinities for IGF1 and IGF2 (Casella et al. 1986, Steele-Perkins et al. 1988). The binding sites for IGF1 and IGF2 are in a similar location on the alpha peptide of IGF1R but there are some differences in which residues of IGF1R interact with IGF1 vs. IGF2 (Keyhanfar et al. 2007, Alvino et al. 2009, Alvino et al. 2011).

Literature References
PubMed ID Title Journal Year
16981855 Precise mapping of an IGF-I-binding site on the IGF-1R

Keyhanfar, M, Booker, GW, Whittaker, J, Wallace, JC, Forbes, BE

Biochem. J. 2007
1845984 Mutants of human insulin-like growth factor II with altered affinities for the type 1 and type 2 insulin-like growth factor receptor

Bürgisser, DM, Roth, BV, Giger, R, Lüthi, C, Weigl, S, Zarn, J, Humbel, RE

J. Biol. Chem. 1991
19139090 A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II

Alvino, CL, McNeil, KA, Ong, SC, Delaine, C, Booker, GW, Wallace, JC, Whittaker, J, Forbes, BE

J. Biol. Chem. 2009
1310594 Expression of a type I insulin-like growth factor receptor with low affinity for insulin-like growth factor II

Germain-Lee, EL, Janicot, M, Lammers, R, Ullrich, A, Casella, SJ

Biochem. J. 1992
22140443 Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II

Alvino, CL, Ong, SC, McNeil, KA, Delaine, C, Booker, GW, Wallace, JC, Forbes, BE

PLoS ONE 2011
2839228 Mutants of human insulin-like growth factor I with reduced affinity for the type 1 insulin-like growth factor receptor

Cascieri, MA, Chicchi, GG, Applebaum, J, Hayes, NS, Green, BG, Bayne, ML

Biochemistry 1988
2969892 Expression and characterization of a functional human insulin-like growth factor I receptor

Steele-Perkins, G, Turner, J, Edman, JC, Hari, J, Pierce, SB, Stover, C, Rutter, WJ, Roth, RA

J. Biol. Chem. 1988
3011795 Purification of insulin-like growth factor I receptor from human placental membranes

LeBon, TR, Jacobs, S, Cuatrecasas, P, Kathuria, S, Fujita-Yamaguchi, Y

J. Biol. Chem. 1986
3013881 Insulin-like growth factor II binding to the type I somatomedin receptor. Evidence for two high affinity binding sites

Casella, SJ, Han, VK, D'Ercole, AJ, Svoboda, ME, Van Wyk, JJ

J. Biol. Chem. 1986
3019338 Characterization of affinity-purified type I insulin-like growth factor receptor from human placenta

Maly, P, Lüthi, C

Biochem. Biophys. Res. Commun. 1986
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
IGF1,2 binds IGF1R (Canis familiaris)
IGF1,2 binds IGF1R (Danio rerio)
IGF1,2 binds IGF1R (Gallus gallus)
IGF1,2 binds IGF1R (Mus musculus)
IGF1,2 binds IGF1R (Rattus norvegicus)
IGF1,2 binds IGF1R (Xenopus tropicalis)
Authored
May, B  (2012-07-08)
Reviewed
Holzenberger, M  (2012-11-10)
Created
May, B  (2012-07-16)