Reactome | IGF1,2 binds IGF1R

IGF1,2 binds IGF1R

Stable Identifier

R-HSA-2404200

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Either IGF1 (IGF-I) or IGF2 (IGF-II) can bind the type 1 insulin-like growth factor receptor (IGF1R) (Casella et al. 1986, LeBon et al. 1986, Maly and Luthi 1986, Cacieri et al. 1988, Steele-Perkins et al. 1988, Burgisser et al. 1991, Germain-Lee et al. 1992, Keyhanfar et al. 2007, Alvino et al. 2009, Alvino et al. 2011). IGF1R has similar affinities for IGF1 and IGF2 (Casella et al. 1986, Steele-Perkins et al. 1988). The binding sites for IGF1 and IGF2 are in a similar location on the alpha peptide of IGF1R but there are some differences in which residues of IGF1R interact with IGF1 vs. IGF2 (Keyhanfar et al. 2007, Alvino et al. 2009, Alvino et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
1845984	Mutants of human insulin-like growth factor II with altered affinities for the type 1 and type 2 insulin-like growth factor receptor Humbel, RE, Lüthi, C, Weigl, S, Giger, R, Zarn, J, Bürgisser, DM, Roth, BV	J. Biol. Chem.	1991
16981855	Precise mapping of an IGF-I-binding site on the IGF-1R Forbes, BE, Booker, GW, Whittaker, J, Keyhanfar, M, Wallace, JC	Biochem. J.	2007
19139090	A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II Forbes, BE, Delaine, C, Booker, GW, Whittaker, J, Wallace, JC, Alvino, CL, Ong, SC, McNeil, KA	J. Biol. Chem.	2009
1310594	Expression of a type I insulin-like growth factor receptor with low affinity for insulin-like growth factor II Janicot, M, Lammers, R, Germain-Lee, EL, Ullrich, A, Casella, SJ	Biochem. J.	1992
22140443	Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II Forbes, BE, Delaine, C, Booker, GW, Wallace, JC, Alvino, CL, Ong, SC, McNeil, KA	PLoS ONE	2011
2839228	Mutants of human insulin-like growth factor I with reduced affinity for the type 1 insulin-like growth factor receptor Applebaum, J, Green, BG, Cascieri, MA, Bayne, ML, Hayes, NS, Chicchi, GG	Biochemistry	1988
2969892	Expression and characterization of a functional human insulin-like growth factor I receptor Pierce, SB, Hari, J, Roth, RA, Rutter, WJ, Stover, C, Edman, JC, Turner, J, Steele-Perkins, G	J. Biol. Chem.	1988
3011795	Purification of insulin-like growth factor I receptor from human placental membranes Fujita-Yamaguchi, Y, LeBon, TR, Jacobs, S, Kathuria, S, Cuatrecasas, P	J. Biol. Chem.	1986
3013881	Insulin-like growth factor II binding to the type I somatomedin receptor. Evidence for two high affinity binding sites Svoboda, ME, D'Ercole, AJ, Van Wyk, JJ, Han, VK, Casella, SJ	J. Biol. Chem.	1986
3019338	Characterization of affinity-purified type I insulin-like growth factor receptor from human placenta Maly, P, Lüthi, C	Biochem. Biophys. Res. Commun.	1986