RBP4 binds atROL

Stable Identifier
Reaction [binding]
Homo sapiens
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At the stellate cell surface, all-trans-retinol (atROL) binds to retinol binding protein 4 (RBP4, holo-RBP) (Kanai et al. 1968). atROL is insoluble in aqueous conditions and it's thought RBP4 picks up atROL from the outer leaflet of the plasma membrane. RBP4 is a 21 kDa protein secreted into the bloodstream by the liver in an atROL-dependent manner. Defects in RBP4 cause retinol-binding protein deficiency (RBP deficiency, MIM:180250), causing night vision problems and progressive atrophy of the retinal pigment epithelium (RPE) (Seeliger et al. 1999).

Literature References
PubMed ID Title Journal Year
5675424 Retinol-binding protein: the transport protein for vitamin A in human plasma

Raz, A, Goodman, DS, Kanai, M

J. Clin. Invest. 1968
9888420 Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis

Seeliger, MW, Zrenner, E, Gollnick, H, Gielen, S, Wissinger, B, Beck, S, Biesalski, HK, Frank, J

Invest. Ophthalmol. Vis. Sci. 1999
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