Reactome | RBP4 binds atROL

RBP4 binds atROL

Stable Identifier

R-HSA-2404135

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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At the stellate cell surface, all-trans-retinol (atROL) binds to retinol binding protein 4 (RBP4, holo-RBP) (Kanai et al. 1968). atROL is insoluble in aqueous conditions and it's thought RBP4 picks up atROL from the outer leaflet of the plasma membrane. RBP4 is a 21 kDa protein secreted into the bloodstream by the liver in an atROL-dependent manner. Defects in RBP4 cause retinol-binding protein deficiency (RBP deficiency, MIM:180250), causing night vision problems and progressive atrophy of the retinal pigment epithelium (RPE) (Seeliger et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
5675424	Retinol-binding protein: the transport protein for vitamin A in human plasma Kanai, M, Raz, A, Goodman, DS	J. Clin. Invest.	1968
9888420	Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis Seeliger, MW, Biesalski, HK, Wissinger, B, Gollnick, H, Gielen, S, Frank, J, Beck, S, Zrenner, E	Invest. Ophthalmol. Vis. Sci.	1999