RBP4 binds atROL

Stable Identifier
R-HSA-2404135
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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At the stellate cell surface, all-trans-retinol (atROL) binds to retinol binding protein 4 (RBP4, holo-RBP) (Kanai et al. 1968). atROL is insoluble in aqueous conditions and it's thought RBP4 picks up atROL from the outer leaflet of the plasma membrane. RBP4 is a 21 kDa protein secreted into the bloodstream by the liver in an atROL-dependent manner. Defects in RBP4 cause retinol-binding protein deficiency (RBP deficiency, MIM:180250), causing night vision problems and progressive atrophy of the retinal pigment epithelium (RPE) (Seeliger et al. 1999).

Literature References
PubMed ID Title Journal Year
9888420 Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis

Seeliger, MW, Biesalski, HK, Wissinger, B, Gollnick, H, Gielen, S, Frank, J, Beck, S, Zrenner, E

Invest. Ophthalmol. Vis. Sci. 1999
5675424 Retinol-binding protein: the transport protein for vitamin A in human plasma

Kanai, M, Raz, A, Goodman, DS

J. Clin. Invest. 1968
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