A REH hydrolses atREs to atROL and FAs

Stable Identifier
R-HSA-2404133
Type
Reaction [omitted]
Species
Homo sapiens
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Retinyl esters (REs) are stored in lipid droplets (LDs) in hepatic stellate cells (HSCs) until there is a demand for retinoid by the body. Mobilization of atREs stores require lipases with retinyl ester hydrolase (REH) activity. At present, the identity of the REH mediating atRE mobilization is unknown (see reviews Shirakami et al. 2012, Schreiber et al. 2012). In studies performed with rat livers, Mello et al. found that the carboxylesterases ES4 and ES10 possessed REH activity and were localised to HSCs (Mello et al. 2008) but it's not confirmed that these are the actual REHs involved in retinoid mobilization. The human orthologue to these rat enzymes is presently unknown.

Literature References
PubMed ID Title Journal Year
21586336 Retinyl ester hydrolases and their roles in vitamin A homeostasis

Schreiber, R, Taschler, U, Preiss-Landl, K, Wongsiriroj, N, Zimmermann, R, Lass, A

Biochim. Biophys. Acta 2012
18639528 Expression of carboxylesterase and lipase genes in rat liver cell-types

Mello, T, Nakatsuka, A, Fears, S, Davis, W, Tsukamoto, H, Bosron, WF, Sanghani, SP

Biochem. Biophys. Res. Commun. 2008
21763780 Hepatic metabolism of retinoids and disease associations

Shirakami, Y, Lee, SA, Clugston, RD, Blaner, WS

Biochim. Biophys. Acta 2012
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Catalyst Activity
Title
retinyl-palmitate esterase activity of REH [cytosol]
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