LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol

Stable Identifier
R-HSA-2404131
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Remnant CMs bound to apoE and HSPG are cleared by LDL receptor-related proteins
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

When the low-density lipoprotein receptor (LDLR) is missing, saturated or inhibited, chylomicron remnants (CRs) containing all-trans-retinyl esters (atREs) can be cleared from circulation by interaction with cell-surface heparan sulfate proteoglycan (HSPG) and secreted apolipoprotein E (apoE). This complex is then presented to LDL receptor-related proteins (LRPs; reviews May et al. 2007, Li et al. 2001, Hussain 2001) for internalization (Ji et al. 1993).

Literature References
PubMed ID Title Journal Year
7683668 Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells

Ji, ZS, Brecht, WJ, Miranda, RD, Hussain, MM, Innerarity, TL, Mahley, RW

J. Biol. Chem. 1993
Participants
Participates
Catalyst Activity

low-density lipoprotein particle receptor activity of LRPs [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!