Reactome | LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol

LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol

Stable Identifier

R-HSA-2404131

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, early endosome

Synonyms

Remnant CMs bound to apoE and HSPG are cleared by LDL receptor-related proteins

ReviewStatus

5/5

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LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol

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When the low-density lipoprotein receptor (LDLR) is missing, saturated or inhibited, chylomicron remnants (CRs) containing all-trans-retinyl esters (atREs) can be cleared from circulation by interaction with cell-surface heparan sulfate proteoglycan (HSPG) and secreted apolipoprotein E (apoE). This complex is then presented to LDL receptor-related proteins (LRPs; reviews May et al. 2007, Li et al. 2001, Hussain 2001) for internalization (Ji et al. 1993).

Literature References

PubMed ID	Title	Journal	Year
7683668	Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells Hussain, MM, Mahley, RW, Miranda, RD, Innerarity, TL, Brecht, WJ, Ji, ZS	J. Biol. Chem.	1993