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p-5Y-LAT-2 [plasma membrane]
Stable Identifier
R-HSA-2396597
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-5Y-LAT isoform 2, Linker for activation of T-cells family member 1 isoform 2
Locations in the PathwayBrowser for interactor UniProt:Q9Y676 MRPS18B
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
Phosphorylation of LAT by p-SYK (Homo sapiens)
p-5Y-LAT-2 [plasma membrane] (Homo sapiens)
Recruitment of GRB2:SOS to p-5Y-LAT (Homo sapiens)
p-5Y-LAT-2 [plasma membrane] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Recruitment of GRB2:SOS to p-5Y-LAT (Homo sapiens)
p-5Y-LAT-2 [plasma membrane] (Homo sapiens)
Phosphorylation of LAT by p-SYK (Homo sapiens)
p-5Y-LAT-2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43561-2 LAT
Gene Names
LAT
Other Identifiers
11726777_a_at
11743748_a_at
16817537
209881_PM_s_at
209881_s_at
211005_PM_at
211005_at
27040
3654964
3654965
3654966
3654967
3654969
3654970
3654972
3654974
3654975
3654976
3654977
3654978
3654981
3654983
3654984
3654985
3654986
3654987
40688_at
7994535
7994541
A_23_P44105
A_23_P44112
GE55241
GE81922
GO:0001772
GO:0002250
GO:0002260
GO:0002376
GO:0005515
GO:0005634
GO:0005794
GO:0005886
GO:0005911
GO:0006954
GO:0006955
GO:0007165
GO:0007229
GO:0007265
GO:0008180
GO:0010467
GO:0016020
GO:0016192
GO:0019722
GO:0019901
GO:0023052
GO:0030159
GO:0035556
GO:0036211
GO:0042110
GO:0043226
GO:0043303
GO:0045121
GO:0045860
GO:0048872
GO:0050852
GO:0050863
GO:0060090
HMNXSV003017433
ILMN_1691539
ILMN_1750188
ILMN_2281320
ILMN_2404625
PH_hs_0026523
PH_hs_0034136
g2828023_3p_a_at
g2828025_3p_at
p33449
p33450
Participates
as an output of
Phosphorylation of LAT by p-SYK (Homo sapiens)
Phosphorylation of LAT by p-SYK (Homo sapiens)
as an input of
Recruitment of GRB2:SOS to p-5Y-LAT (Homo sapiens)
as a component of
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
LAT-2 [plasma membrane]
Inferred To
Ghost homologue of p-5Y-LAT-2 [plasma membrane]
(Drosophila melanogaster)
Ghost homologue of p-5Y-LAT-2 [plasma membrane]
(Gallus gallus)
Ghost homologue of p-5Y-LAT-2 [plasma membrane]
(Xenopus tropicalis)
phospho-LAT [plasma membrane]
(Bos taurus)
phospho-LAT [plasma membrane]
(Canis familiaris)
phospho-LAT [plasma membrane]
(Sus scrofa)
phospho-Lat [plasma membrane]
(Mus musculus)
phospho-Lat [plasma membrane]
(Rattus norvegicus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 127
Coordinate
127
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 132
Coordinate
132
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 171
Coordinate
171
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 191
Coordinate
191
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 226
Coordinate
226
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_055202.1
,
NP_001014988.1
,
NP_001014989.2
,
NP_001014987.1
OpenTargets
ENSG00000213658
GeneCards
O43561
HPA
ENSG00000213658-LAT
Ensembl
ENSP00000354119
,
ENSP00000378845
,
ENSP00000378841
,
ENSP00000456761
,
ENSP00000457036
,
ENSP00000398793
,
ENST00000395456
,
ENST00000395461
,
ENSG00000213658
,
ENST00000360872
,
ENST00000564277
,
ENST00000454369
,
ENST00000566177
PRO
O43561
Pharos - Targets
O43561
Orphanet
26797
HMDB Protein
HMDBP07770
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19174 PLCG1
6
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
0.81
7
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.708
7
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.635
3
UniProt:P18031 PTPN1
2
PTPN1 [cytosol]
(R-HSA-210625)
PTPN1 [endosome membrane]
(R-HSA-9815895)
0.591
3
UniProt:O43765 SGTA
1
SGTA [cytosol]
(R-HSA-5423595)
0.556
3
UniProt:P06239 LCK
4
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.525
2
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.462
4
UniProt:Q8N1K5 THMS1
0.462
2
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