SLP-76 lacks intrinsic catalytic activity and acts as a scaffold, recruiting other proteins for correct localization during molecular signal transduction (Bogin et al. 2007). Activation of DAP12-associated receptors leads to tyrosine phosphorylation of SLP-76 (Gross et al. 1999). SLP-76 has three potential tyrosine phosphorylation sites within its amino terminus region: Y113, Y128, and Y145. Phosphorylation may be mediated by SYK, analogous to the role of ZAP-70 in phosphorylating T-cell SLP-76 (Bubeck-Wardenberg et al. 1996).
Gross, BS, Lee, JR, Clements, JL, Turner, M, Tybulewicz, VL, Findell, PR, Koretzky, GA, Watson, SP
Reeve, JL, Zou, W, Liu, Y, Maltzman, JS, Ross, FP, Teitelbaum, SL
Bubeck Wardenburg, J, Fu, C, Jackman, JK, Flotow, H, Wilkinson, SE, Williams, DH, Johnson, R, Kong, G, Chan, AC, Findell, PR
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