Reactome | LAT-2 [plasma membrane]

LAT-2 [plasma membrane]

Stable Identifier

R-HSA-2396548

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Linker for activation of T-cells family member 1, LAT_HUMAN, LAT isoform 2

Locations in the PathwayBrowser for interactor UniProt:Q9Y676 MRPS18B

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External Reference Information

External Reference

UniProt:O43561-2 LAT

Gene Names

LAT

Other Identifiers

11726777_a_at

11743748_a_at

16817537

209881_PM_s_at

209881_s_at

211005_PM_at

211005_at

27040

3654964

3654965

3654966

3654967

3654969

3654970

3654972

3654974

3654975

3654976

3654977

3654978

3654981

3654983

3654984

3654985

3654986

3654987

40688_at

7994535

7994541

A_23_P44105

A_23_P44112

GE55241

GE81922

GO:0001772

GO:0002250

GO:0002260

GO:0002376

GO:0005515

GO:0005634

GO:0005794

GO:0005886

GO:0005911

GO:0006954

GO:0006955

GO:0007165

GO:0007229

GO:0007265

GO:0008180

GO:0010467

GO:0016020

GO:0016192

GO:0019722

GO:0019901

GO:0023052

GO:0030159

GO:0035556

GO:0036211

GO:0042110

GO:0043226

GO:0043303

GO:0045121

GO:0045860

GO:0048872

GO:0050852

GO:0050863

GO:0060090

HMNXSV003017433

ILMN_1691539

ILMN_1750188

ILMN_2281320

ILMN_2404625

PH_hs_0026523

PH_hs_0034136

g2828023_3p_a_at

g2828025_3p_at

p33449

p33450

Participates

as an input of

Other forms of this molecule

p-5Y-LAT-2 [plasma membrane]

Inferred To

LAT [plasma membrane] (Bos taurus)

LAT [plasma membrane] (Canis familiaris)

LAT [plasma membrane] (Sus scrofa)

Lat [plasma membrane] (Mus musculus)

Lat [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_055202.1, NP_001014988.1, NP_001014989.2, NP_001014987.1

OpenTargets

ENSG00000213658

GeneCards

O43561

HPA

ENSG00000213658-LAT

Ensembl

ENSP00000354119, ENSP00000378845, ENSP00000378841, ENSP00000456761, ENSP00000457036, ENSP00000398793, ENST00000395456, ENST00000395461, ENSG00000213658, ENST00000360872, ENST00000564277, ENST00000454369, ENST00000566177

PRO

O43561

Pharos - Targets

O43561

Orphanet

26797

HMDB Protein

HMDBP07770

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19174 PLCG1	6	p-Y-PLCG1 [cytosol] (R-HSA-9029082) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084)	0.81	7
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.708	7
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.635	3
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.591	3
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.556	3
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.525	2
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.462	4
UniProt:Q8N1K5 THMS1			0.462	2

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