Fibrillins bind BMPs

Stable Identifier
R-HSA-2396399
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
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Fibrillins bind BMPs
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Fibrillins can bind the prodomains of TGF-beta superfamily members bone morphogenic factor (BMP) 2, 4, 7, 10, and growth and differentiation factor (GDF) 5 (Sengle et al. 2008). Prodomain binding by ECM constituents may be a targeting mechanism for TGF family members (Sengle et al. 2011).

Literature References
PubMed ID Title Journal Year
18339631 Targeting of bone morphogenetic protein growth factor complexes to fibrillin

Sakai, LY, Alvarez, J, Ono, RN, Bächinger, HP, Keene, DR, Charbonneau, NL, Sasaki, T, Sengle, G

J. Biol. Chem. 2008
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as an event of
Orthologous Events
Fibrillins bind BMPs (Bos taurus)
Fibrillins bind BMPs (Caenorhabditis elegans)
Fibrillins bind BMPs (Canis familiaris)
Fibrillins bind BMPs (Danio rerio)
Fibrillins bind BMPs (Gallus gallus)
Fibrillins bind BMPs (Mus musculus)
Fibrillins bind BMPs (Rattus norvegicus)
Fibrillins bind BMPs (Sus scrofa)
Authored
Jupe, S  (2012-04-30)
Reviewed
Muiznieks, LD  (2012-11-02)
Created
Jupe, S  (2012-07-09)
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