Fibrillins bind BMPs

Stable Identifier
R-HSA-2396399
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
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Fibrillins bind BMPs
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Fibrillins can bind the prodomains of TGF-beta superfamily members bone morphogenic factor (BMP) 2, 4, 7, 10, and growth and differentiation factor (GDF) 5 (Sengle et al. 2008). Prodomain binding by ECM constituents may be a targeting mechanism for TGF family members (Sengle et al. 2011).

Literature References
PubMed ID Title Journal Year
18339631 Targeting of bone morphogenetic protein growth factor complexes to fibrillin

Sengle, G, Charbonneau, NL, Ono, RN, Sasaki, T, Alvarez, J, Keene, DR, Bächinger, HP, Sakai, LY

J. Biol. Chem. 2008
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
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Fibrillins bind BMPs (Gallus gallus)
Fibrillins bind BMPs (Mus musculus)
Fibrillins bind BMPs (Rattus norvegicus)
Fibrillins bind BMPs (Sus scrofa)
Fibrillins bind BMPs (Xenopus tropicalis)
Authored
Jupe, S  (2012-04-30)
Reviewed
Muiznieks, LD  (2012-11-02)
Created
Jupe, S  (2012-07-09)
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