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Laminins bind galactosyl sulfatide and related sulfated glycolipids
Stable Identifier
R-HSA-2396083
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
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Extracellular matrix organization (Homo sapiens)
Laminin interactions (Homo sapiens)
Laminins bind galactosyl sulfatide and related sulfated glycolipids (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Sulfated glycolipids (SGs) such as the sulfatides bind strongly to the LG domains of laminin (Roberts et al. 1985, 1986, Ishizuka 1997). The most common SG, HSO3-3galactosylBeta-1ceramide (galactosyl-3-sulfate ceramide or sulfatide) is highly expressed in developing and adult peripheral nerves (Mirsky et al. 1990), Schwann cells, kidney and other tissues. SGs are thought to mediate or enhance the cell surface anchorage of laminins, possibly by allowing the short arms to bind the cell surface in addition to the LG domains (Li et al. 2005, Yurchenko & Patton 2009).
Participants
Input
Laminins [extracellular region]
(Homo sapiens)
Sulfatide [plasma membrane]
Output
Laminins:Sulfatide [plasma membrane]
(Homo sapiens)
Participates
as an event of
Laminin interactions (Homo sapiens)
Inferred From
Laminin binds galactosyl sulfatide and related sulfated glycolipids (Mus musculus)
Authored
Jupe, S (2012-08-08)
Reviewed
Ricard-Blum, S (2013-08-13)
Created
Jupe, S (2012-07-09)
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