Reactome | Electron transport from NADPH to Ferredoxin

Electron transport from NADPH to Ferredoxin

Stable Identifier

R-HSA-2395516

Type

Pathway

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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Electron transport from NADPH to Ferredoxin

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NADPH, ferredoxin reductase (FDXR, Adrenodoxin reductase), and ferredoxins (FDX1, FDX1L) comprise a short electron transport chain that provides electrons for biosynthesis of iron-sulfur clusters and steroid hormones (Sheftel et al. 2010, Shi et al. 2012, reviewed in Grinberg et al. 2000, Lambeth et al. 1982).

Literature References

PubMed ID	Title	Journal	Year
10899784	Adrenodoxin: structure, stability, and electron transfer properties Bernhardt, R, Heinemann, U, Schiffler, B, Grinberg, AV, Müller, J, Hannemann, F	Proteins	2000
20547883	Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis Hobler, A, Webert, H, Pierik, AJ, Lill, R, Elsässer, HP, Bernhardt, R, Stehling, O, Sheftel, AD, Hannemann, F, Mühlenhoff, U	Proc. Natl. Acad. Sci. U.S.A.	2010
7050653	Steroidogenic electron transport in adrenal cortex mitochondria Kamin, H, Seybert, DW, Lancaster, JR, Lambeth, JD, Salerno, JC	Mol. Cell. Biochem.	1982
22101253	Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis Shi, Y, Kovtunovych, G, Crooks, DR, Ghosh, M, Rouault, TA	Biochim. Biophys. Acta	2012