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FDXR [mitochondrial matrix]
Stable Identifier
R-HSA-2395499
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
NADPH:adrenodoxin oxidoreductase, mitochondrial, ADRO_HUMAN, Ferredoxin reductase
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Metabolic disorders of biological oxidation enzymes (Homo sapiens)
Defective CYP11A1 causes AICSR (Homo sapiens)
Defective CYP11A1 does not cleave 20a,22b-DHCHOL (Homo sapiens)
CYP11A1 mutants:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix] (Homo sapiens)
FDXR [mitochondrial matrix] (Homo sapiens)
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Endogenous sterols (Homo sapiens)
CYP11A1 cleaves 20a,22b-DHCHOL (Homo sapiens)
CYP11A1:FDXR:FDX1,FDX1L (ox.) [mitochondrial matrix] (Homo sapiens)
FDXR [mitochondrial matrix] (Homo sapiens)
CYP11A1:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix] (Homo sapiens)
FDXR [mitochondrial matrix] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Metabolism of steroid hormones (Homo sapiens)
Pregnenolone biosynthesis (Homo sapiens)
CYP11A1 cleaves 20a,22b-DHCHOL (Homo sapiens)
CYP11A1:FDXR:FDX1,FDX1L (ox.) [mitochondrial matrix] (Homo sapiens)
FDXR [mitochondrial matrix] (Homo sapiens)
CYP11A1:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix] (Homo sapiens)
FDXR [mitochondrial matrix] (Homo sapiens)
Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Homo sapiens)
CYP11A1:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix] (Homo sapiens)
FDXR [mitochondrial matrix] (Homo sapiens)
Oxidation of cholesterol to 22beta-hydroxycholesterol (Homo sapiens)
CYP11A1:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix] (Homo sapiens)
FDXR [mitochondrial matrix] (Homo sapiens)
Mitochondrial iron-sulfur cluster biogenesis (Homo sapiens)
Electron transport from NADPH to Ferredoxin (Homo sapiens)
FDXR transfers electrons to FDX1,2 (FDX1L) (Homo sapiens)
FDXR [mitochondrial matrix] (Homo sapiens)
FDXR:FAD [mitochondrial matrix] (Homo sapiens)
FDXR [mitochondrial matrix] (Homo sapiens)
FDXR:FADH2 [mitochondrial matrix] (Homo sapiens)
FDXR [mitochondrial matrix] (Homo sapiens)
NADPH transfers electrons to FDXR (Homo sapiens)
FDXR [mitochondrial matrix] (Homo sapiens)
FDXR:FAD [mitochondrial matrix] (Homo sapiens)
FDXR [mitochondrial matrix] (Homo sapiens)
FDXR:FADH2 [mitochondrial matrix] (Homo sapiens)
FDXR [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22570 FDXR
Gene Names
FDXR, ADXR
Chain
transit peptide:1-32, chain:33-491
Reference Genes
BioGPS Gene:2232 FDXR
COSMIC (genes):FDXR FDXR
CTD Gene:2232 FDXR
dbSNP Gene:2232 FDXR
ENSEMBL:ENSG00000161513 FDXR
HGNC:3642 FDXR
KEGG:hsa:2232 FDXR
Monarch:2232 FDXR
NCBI Gene:2232 FDXR
OMIM:103270 FDXR
UCSC:P22570 FDXR
Reference Transcript
RefSeq:NM_024417.4 FDXR
RefSeq:NM_001258014.3 FDXR
RefSeq:NM_001258016.3 FDXR
RefSeq:NM_001258013.3 FDXR
RefSeq:NM_001258015.3 FDXR
RefSeq:NM_001258012.3 FDXR
RefSeq:NM_004110.5 FDXR
Other Identifiers
11732955_a_at
11748117_a_at
11756481_x_at
16848657
207813_PM_s_at
207813_s_at
2232
3770454
3770455
3770456
3770458
3770459
3770460
3770461
3770463
3770464
3770465
3770466
3770467
3770468
3770469
3770470
3770471
3770472
3770473
3770474
3770475
3770476
3770477
3770478
3770479
3770480
3770481
3770482
3770483
3770484
3770485
40336_at
8018236
A_23_P38154
GE57490
GO:0004324
GO:0005739
GO:0005743
GO:0005759
GO:0006091
GO:0006629
GO:0006694
GO:0006744
GO:0008202
GO:0008203
GO:0016020
GO:0016491
HMNXSV003049981
ILMN_1811696
ILMN_2414302
M58509_cds1_s_at
PH_hs_0004109
TC17001864.hg
g13435351_3p_a_at
Participates
as a component of
CYP11A1 mutants:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix] (Homo sapiens)
CYP11A1:FDXR:FDX1,FDX1L (ox.) [mitochondrial matrix] (Homo sapiens)
CYP11A1:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix] (Homo sapiens)
FDXR:FAD [mitochondrial matrix] (Homo sapiens)
FDXR:FADH2 [mitochondrial matrix] (Homo sapiens)
Inferred To
dare [mitochondrial matrix]
(Drosophila melanogaster)
fdxr [mitochondrial matrix]
(Danio rerio)
fdxr [mitochondrial matrix]
(Dictyostelium discoideum)
fdxr [mitochondrial matrix]
(Xenopus tropicalis)
arh1 [mitochondrial matrix]
(Schizosaccharomyces pombe)
Fdxr [mitochondrial matrix]
(Mus musculus)
Fdxr [mitochondrial matrix]
(Rattus norvegicus)
ARH1 [mitochondrial matrix]
(Saccharomyces cerevisiae)
FDXR [mitochondrial matrix]
(Bos taurus)
FDXR [mitochondrial matrix]
(Caenorhabditis elegans)
FDXR [mitochondrial matrix]
(Canis familiaris)
FDXR [mitochondrial matrix]
(Gallus gallus)
FDXR [mitochondrial matrix]
(Plasmodium falciparum)
FDXR [mitochondrial matrix]
(Sus scrofa)
Cross References
RefSeq
NP_001244941.2
,
NP_077728.3
,
NP_001244942.2
,
NP_001244943.2
,
NP_001244944.1
,
NP_001244945.2
,
NP_004101.3
ENSEMBL
ENSG00000161513
,
ENST00000420580
,
ENSP00000414172
OpenTargets
ENSG00000161513
IntEnz
1.18.1.6
GeneCards
FDXR
HPA
ENSG00000161513-FDXR
PRO
P22570
Pharos - Targets
P22570
GlyGen
P22570
Orphanet
FDXR
HMDB Protein
HMDBP00204
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