Reactome | Formation of hydroxylysyl-pyrrole cross-links

Formation of hydroxylysyl-pyrrole cross-links

Stable Identifier

R-HSA-2395324

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Formation of hydroxylysyl-pyrrole cross-links

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Trivalent collagen cross-links can form as pyrroles. Hydroxylysyl-Pyrrole (HL-Pyrrole) is formed when Hydroxylysino-ketonorleucine (HLKNL) reacts with hydroxylysino-norleucine (deH-HLNL) (Eyre et al. 2008). The mechanism of pyrrole cross-links has been revised to a structure based on 3-hydroxypyrrole, rather than a pyrrole lacking a hydroxyl on the ring as depicted earlier (Bailey et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
	A collagen-associated Ehrlich chromogen: a pyrrolic cross-link? Scott, JE, Shuttleworth, A, Hughes, EW	Bioscience Reports	1981
12211432	Mechanical properties of adult vertebral cancellous bone: correlation with collagen intermolecular cross-links Bailey, AJ, Sims, TJ, Banse, X	J. Bone Miner. Res.	2002
1567360	Identification of the loci of the collagen-associated Ehrlich chromogen in type I collagen confirms its role as a trivalent cross-link Tyler, M, Jenkins, ID, Kuypers, R, Horgan, DJ, Kurth, LB	Biochem J	1992