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Formation of lysyl-pyridinoline cross-links
Stable Identifier
R-HSA-2395322
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
Crosslinking of collagen fibrils (Homo sapiens)
Formation of lysyl-pyridinoline cross-links (Homo sapiens)
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Lysyl-pyridinoline (L-Pyr) cross-links are formed from two hydroxylysine residues and a lysine residue (LKNL plus a further hydroxyallysine contributed by HLKNL), found mostly in calcified tissues (Bailey et al. 1998).
Literature References
PubMed ID
Title
Journal
Year
6129847
Collagen cross-linking: lysyl oxidase dependent synthesis of pyridinoline in vitro: confirmation that pyridinoline is derived from collagen
Fu, JC
,
Uto, N
,
Siegel, RC
,
Horiuchi, K
,
Fujimoto, D
Biochem. Biophys. Res. Commun.
1982
Participants
Input
Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region]
(Homo sapiens)
Collagen type I fibrils with lysino-5-ketonorleucine cross-links [extracellular region]
(Homo sapiens)
Output
Collagen type I fibrils with lysyl-pyridinoline cross-links [extracellular region]
(Homo sapiens)
Participates
as an event of
Crosslinking of collagen fibrils (Homo sapiens)
Orthologous Events
Formation of lysyl-pyridinoline cross-links (Bos taurus)
Formation of lysyl-pyridinoline cross-links (Caenorhabditis elegans)
Formation of lysyl-pyridinoline cross-links (Canis familiaris)
Formation of lysyl-pyridinoline cross-links (Danio rerio)
Formation of lysyl-pyridinoline cross-links (Gallus gallus)
Formation of lysyl-pyridinoline cross-links (Mus musculus)
Formation of lysyl-pyridinoline cross-links (Rattus norvegicus)
Formation of lysyl-pyridinoline cross-links (Sus scrofa)
Formation of lysyl-pyridinoline cross-links (Xenopus tropicalis)
Authored
Jupe, S (2012-04-30)
Reviewed
Raleigh, S (2012-10-08)
Ricard-Blum, S (2012-11-19)
Kalamajski, S (2012-10-08)
Created
Jupe, S (2012-06-29)
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