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Formation of hydroxylysino-5-ketonorleucine cross-links
Stable Identifier
R-HSA-2395302
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
Crosslinking of collagen fibrils (Homo sapiens)
Formation of hydroxylysino-5-ketonorleucine cross-links (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Hydroxyallysine and hydroxylysine can react forming the Schiff base, which spontaneously undergoes an Amadori rearrangement resulting in the ketoimine cross-link hydroxylysino-5-ketonorleucine (HLKNL). This is much more stable than the aldimine crosslinks (Bailey et al. 1998).
Literature References
PubMed ID
Title
Journal
Year
1348714
Enzymatic and nonenzymatic cross-linking of collagen and elastin
Reiser, K
,
McCormick, RJ
,
Rucker, RB
FASEB J.
1992
3992061
Skeletal muscle injury--molecular changes in the collagen during healing
Bailey, AJ
,
Lehto, M
,
Sims, TJ
Res Exp Med (Berl)
1985
Participants
Input
Collagen type I fibril [extracellular region]
(Homo sapiens)
Collagen type I fibril with hydroxyallysines [extracellular region]
(Homo sapiens)
Output
Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region]
(Homo sapiens)
Participates
as an event of
Crosslinking of collagen fibrils (Homo sapiens)
Orthologous Events
Formation of hydroxylysino-5-ketonorleucine cross-links (Bos taurus)
Formation of hydroxylysino-5-ketonorleucine cross-links (Caenorhabditis elegans)
Formation of hydroxylysino-5-ketonorleucine cross-links (Canis familiaris)
Formation of hydroxylysino-5-ketonorleucine cross-links (Danio rerio)
Formation of hydroxylysino-5-ketonorleucine cross-links (Gallus gallus)
Formation of hydroxylysino-5-ketonorleucine cross-links (Mus musculus)
Formation of hydroxylysino-5-ketonorleucine cross-links (Rattus norvegicus)
Formation of hydroxylysino-5-ketonorleucine cross-links (Sus scrofa)
Formation of hydroxylysino-5-ketonorleucine cross-links (Xenopus tropicalis)
Authored
Jupe, S (2012-04-30)
Reviewed
Raleigh, S (2012-10-08)
Ricard-Blum, S (2012-11-19)
Kalamajski, S (2012-10-08)
Created
Jupe, S (2012-06-29)
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