Reactome | Formation of hydroxylysyl-pyridinoline cross-links

Formation of hydroxylysyl-pyridinoline cross-links

Stable Identifier

R-HSA-2395223

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Formation of hydroxylysyl-pyridinoline cross-links

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Hydroxylysyl-pyridinoline (HL-Pyr) is formed from three hydroxylysine residues, (HLKNL plus a further hydroxyallysine donated by a second HLKNL). It predominates in highly hydroxylated collagens such as type II collagen in cartilage.

Literature References

PubMed ID	Title	Journal	Year
641035	Pyridinoline, a non-reducible crosslink of collagen. Quantitative determination, distribution, and isolation of a crosslinked peptide Fujimoto, D, Moriguchi, T	J. Biochem.	1978
1484505	Isolation of hydroxylysyl pyridinoline, a mature collagen crosslink from neonatal rat aorta smooth muscle cell cultures Shaw, HA, Stone, PJ, Bryan-Rhadfi, J, Franzblau, C	Matrix	1992
3595596	Characterisation of a type-I collagen trimeric cross-linked peptide from calf aorta and its cross-linked structure. Detection of pyridinoline by time-of-flight secondary ion-mass spectroscopy and evidence for a new cross-link Henkel, W, Greifendorf, D, Glanville, RW	Eur. J. Biochem.	1987