Fibrillin-1 splice variants that include the RGD sequence located in the fourth 8-cysteine domain mediate cell adhesion, binding integrin alphaVbeta3 (Pfaff et al. 1996), alpha5beta1 (Bax et al. 2003) and alphaVbeta6 (Jovanovic et al. 2008). AlphaVbeta3 has the highest affinity for fibrillin-1. Integrin alphaVbeta3 is a high-affinity fibrillin-1 receptor (K(d) approximately 40 nM), whereas integrins alphaVbeta6 and alpha5beta1 show moderate-affinity (K(d) approximately 450 nM) and low-affinity (K(d) >1 microM) binding respectively (Jovanovic et al. 2008).