Reactome | PHLPP2 [cytosol]

PHLPP2 [cytosol]

Stable Identifier

R-HSA-2327837

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PH domain leucine-rich repeat-containing protein phosphatase 2, PHLPP

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PHLPP dephosphorylates S473 in AKT (Homo sapiens)
        
        PHLPP (Mn2+ cofactor) [cytosol] (Homo sapiens)
        
        PHLPP [cytosol] (Homo sapiens)
        
        PHLPP2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6ZVD8 PHLPP2

Gene Names

PHLPP2, KIAA0931, PHLPPL

Chain

chain:1-1323

Reference Genes

BioGPS Gene:23035 PHLPP2

COSMIC (genes):PHLPP2 PHLPP2

CTD Gene:23035 PHLPP2

dbSNP Gene:23035 PHLPP2

ENSEMBL:ENSG00000040199.18 PHLPP2

HGNC:29149 PHLPP2

KEGG Gene (Homo sapiens):23035 PHLPP2

Monarch:23035 PHLPP2

NCBI Gene:23035 PHLPP2

OMIM:611066 PHLPP2

UCSC:Q6ZVD8 PHLPP2

Reference Transcript

Other Identifiers

0005050132

11723599_a_at

11723600_x_at

11753655_a_at

16828046

213407_PM_at

213407_at

23035

32735_at

3690398

3690401

3697749

3697750

3697751

3697752

3697754

3697755

3697756

3697757

3697760

3697761

3697762

3697763

3697764

3697765

3697768

3697769

3697770

3697772

3697773

3697774

3697778

3697788

3697791

3697792

3697793

3697798

8002571

A_23_P418234

A_33_P3271810

GE53608

GO:0001917

GO:0004721

GO:0004722

GO:0005515

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005929

GO:0006470

GO:0007165

GO:0016020

GO:0016787

GO:0017018

GO:0021766

GO:0023052

GO:0036211

GO:0042622

GO:0043226

GO:0043231

GO:0045171

GO:0046872

GO:0048856

GO:0072686

GO:0140096

HMNXSV003046182

Hs.173373.0.S1_3p_at

ILMN_1746632

ILMN_2083567

PH_hs_0026526

TC16001250.hg

Participates

as a member of

PHLPP [cytosol] (Homo sapiens)

Inferred To

phlp-2 [cytosol] (Caenorhabditis elegans)

PHLPP2 [cytosol] (Canis familiaris)

PHLPP2 [cytosol] (Gallus gallus)

PHLPP2 [cytosol] (Mus musculus)

Phlpp [cytosol] (Drosophila melanogaster)

Lrr47 [cytosol] (Drosophila melanogaster)

Phlpp2 [cytosol] (Rattus norvegicus)

lrrA [cytosol] (Dictyostelium discoideum)

Homologues of PHLPP2 [cytosol] (Drosophila melanogaster)

CT11751 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001275932.1, NP_055835.2

OpenTargets

ENSG00000040199

ZINC - Substances

PHLP2_HUMAN

ZINC target

Q6ZVD8

PRO

Q6ZVD8

IntEnz

3.1.3.16

HPA

ENSG00000040199-PHLPP2

GeneCards

Q6ZVD8

Ensembl

ENSP00000457991, ENST00000568954, ENSG00000040199, ENSP00000377159, ENST00000393524

Pharos - Targets

Q6ZVD8

Orphanet

28978

ZINC - Predictions - Purchasable

PHLP2_HUMAN

HMDB Protein

HMDBP08849

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8TAF3 WDR48	3	WDR48 [nucleoplasm] (R-HSA-419549) WDR48(1-323)-PDGFRB(559-1106) fusion [cytosol] (R-HSA-9673617) p-12Y WDR48(1-323)-PDGFRB(559-1106) fusion [cytosol] (R-HSA-9673645)	0.669	4
UniProt:O94782 USP1	3	USP1(1-671) [nucleoplasm] (R-HSA-5655484) USP1(672-785) [nucleoplasm] (R-HSA-5655474) USP1 [nucleoplasm] (R-HSA-419546)	0.564	2