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PHLPP2 [cytosol]
Stable Identifier
R-HSA-2327837
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PH domain leucine-rich repeat-containing protein phosphatase 2, PHLPP
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PHLPP dephosphorylates S473 in AKT (Homo sapiens)
PHLPP (Mn2+ cofactor) [cytosol] (Homo sapiens)
PHLPP [cytosol] (Homo sapiens)
PHLPP2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6ZVD8 PHLPP2
Gene Names
PHLPP2, KIAA0931, PHLPPL
Chain
chain:1-1323
Reference Genes
BioGPS Gene:23035 PHLPP2
COSMIC (genes):PHLPP2 PHLPP2
CTD Gene:23035 PHLPP2
dbSNP Gene:23035 PHLPP2
ENSEMBL:ENSG00000040199.18 PHLPP2
HGNC:29149 PHLPP2
KEGG Gene (Homo sapiens):23035 PHLPP2
Monarch:23035 PHLPP2
NCBI Gene:23035 PHLPP2
OMIM:611066 PHLPP2
UCSC:Q6ZVD8 PHLPP2
Reference Transcript
RefSeq:NM_015020.3 PHLPP2
RefSeq:NM_001289003.1 PHLPP2
Other Identifiers
0005050132
11723599_a_at
11723600_x_at
11753655_a_at
16828046
213407_PM_at
213407_at
23035
32735_at
3690398
3690401
3697749
3697750
3697751
3697752
3697754
3697755
3697756
3697757
3697760
3697761
3697762
3697763
3697764
3697765
3697768
3697769
3697770
3697772
3697773
3697774
3697778
3697788
3697791
3697792
3697793
3697798
8002571
A_23_P418234
A_33_P3271810
GE53608
GO:0001917
GO:0004721
GO:0004722
GO:0005515
GO:0005576
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005929
GO:0006470
GO:0007165
GO:0016020
GO:0016787
GO:0017018
GO:0021766
GO:0023052
GO:0036211
GO:0042622
GO:0043226
GO:0043231
GO:0045171
GO:0046872
GO:0048856
GO:0072686
GO:0140096
HMNXSV003046182
Hs.173373.0.S1_3p_at
ILMN_1746632
ILMN_2083567
PH_hs_0026526
TC16001250.hg
Participates
as a member of
PHLPP [cytosol] (Homo sapiens)
Inferred To
phlp-2 [cytosol]
(Caenorhabditis elegans)
PHLPP2 [cytosol]
(Canis familiaris)
PHLPP2 [cytosol]
(Gallus gallus)
PHLPP2 [cytosol]
(Mus musculus)
Phlpp [cytosol]
(Drosophila melanogaster)
Lrr47 [cytosol]
(Drosophila melanogaster)
Phlpp2 [cytosol]
(Rattus norvegicus)
lrrA [cytosol]
(Dictyostelium discoideum)
Homologues of PHLPP2 [cytosol]
(Drosophila melanogaster)
CT11751 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001275932.1
,
NP_055835.2
OpenTargets
ENSG00000040199
ZINC - Substances
PHLP2_HUMAN
ZINC target
Q6ZVD8
PRO
Q6ZVD8
IntEnz
3.1.3.16
HPA
ENSG00000040199-PHLPP2
GeneCards
Q6ZVD8
Ensembl
ENSP00000457991
,
ENST00000568954
,
ENSG00000040199
,
ENSP00000377159
,
ENST00000393524
Pharos - Targets
Q6ZVD8
Orphanet
28978
ZINC - Predictions - Purchasable
PHLP2_HUMAN
HMDB Protein
HMDBP08849
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8TAF3 WDR48
3
WDR48 [nucleoplasm]
(R-HSA-419549)
WDR48(1-323)-PDGFRB(559-1106) fusion [cytosol]
(R-HSA-9673617)
p-12Y WDR48(1-323)-PDGFRB(559-1106) fusion [cytosol]
(R-HSA-9673645)
0.669
4
UniProt:O94782 USP1
3
USP1(1-671) [nucleoplasm]
(R-HSA-5655484)
USP1(672-785) [nucleoplasm]
(R-HSA-5655474)
USP1 [nucleoplasm]
(R-HSA-419546)
0.564
2
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