Reactome | PHLPP2 [cytosol]

PHLPP2 [cytosol]

Stable Identifier

R-HSA-2327837

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PH domain leucine-rich repeat-containing protein phosphatase 2, PHLPP

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PHLPP dephosphorylates S473 in AKT (Homo sapiens)
        
        PHLPP (Mn2+ cofactor) [cytosol] (Homo sapiens)
        
        PHLPP [cytosol] (Homo sapiens)
        
        PHLPP2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6ZVD8 PHLPP2

Gene Names

PHLPP2, KIAA0931, PHLPPL

Chain

chain:1-1323

Reference Genes

BioGPS Gene:23035 PHLPP2

COSMIC (genes):PHLPP2 PHLPP2

CTD Gene:23035 PHLPP2

dbSNP Gene:23035 PHLPP2

ENSEMBL:ENSG00000040199 PHLPP2

HGNC:29149 PHLPP2

KEGG:hsa:23035 PHLPP2

Monarch:23035 PHLPP2

NCBI Gene:23035 PHLPP2

OMIM:611066 PHLPP2

UCSC:Q6ZVD8 PHLPP2

Reference Transcript

Other Identifiers

11723599_a_at

11723600_x_at

11753655_a_at

16828046

213407_PM_at

213407_at

214944_PM_at

214944_at

23035

32735_at

3690398

3690401

3697747

3697748

3697749

3697750

3697751

3697752

3697754

3697755

3697756

3697757

3697760

3697761

3697762

3697763

3697764

3697765

3697766

3697767

3697768

3697769

3697770

3697772

3697773

3697774

3697778

3697788

3697791

3697792

3697793

3697797

3697798

8002571

A_23_P418234

A_33_P3271810

GE53608

GE55934

GO:0001917

GO:0003824

GO:0004721

GO:0004722

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0007165

GO:0016020

GO:0016787

GO:0017018

GO:0021766

GO:0042622

GO:0043226

GO:0045171

GO:0046872

GO:0048856

GO:0072686

GO:0140096

HMNXSV003046182

Hs.132339.0.S1_3p_at

Hs.173373.0.S1_3p_at

ILMN_2083567

PH_hs_0026526

PH_hs_0037056

TC16001250.hg

Participates

as a member of

PHLPP [cytosol] (Homo sapiens)

Inferred To

Dmel\CG10307 [cytosol] (Drosophila melanogaster)

PHLPP2 [cytosol] (Gallus gallus)

PHLPP2 [cytosol] (Mus musculus)

Phlpp [cytosol] (Drosophila melanogaster)

Homologues of PHLPP2 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_055835.2, NP_001275932.1

ENSEMBL

ENSP00000377159, ENSP00000457991, ENST00000568954, ENST00000393524

OpenTargets

ENSG00000040199

IntEnz

3.1.3.16

HPA

ENSG00000040199-PHLPP2

ZINC - Substances

PHLP2_HUMAN

ZINC target

Q6ZVD8

PRO

Q6ZVD8

Pharos - Targets

Q6ZVD8

ZINC - Predictions - Purchasable

PHLP2_HUMAN

HMDB Protein

HMDBP08849

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8TAF3 WDR48	3	WDR48 [nucleoplasm] (R-HSA-419549) WDR48(1-323)-PDGFRB(559-1106) fusion [cytosol] (R-HSA-9673617) p-12Y-WDR48(1-323)-PDGFRB(559-1106) fusion [cytosol] (R-HSA-9673645)	0.643	4
UniProt:O94782 USP1	3	USP1 [nucleoplasm] (R-HSA-419546) USP1(672-785) [nucleoplasm] (R-HSA-5655474) USP1(1-671) [nucleoplasm] (R-HSA-5655484)	0.527	2

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