Laminins bind Nidogens 1, 2

Stable Identifier
R-HSA-2327803
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Nidogen-1 and nidogen-2, also known as the entactins, are basement membrane glycoproteins with three globular domains (G1, G2, G3) separated by rod-like regions. They form stable complexes with laminins and collagen IV (Fox et al. 1991, Talts et al. 1999, Salmivirta et al. 2002), thereby acting as a major linking agent between these two networks in basement membrane ECM (Nischt et al. 2007). Interactions mediated by HSPG2 (perlecan) (Behrens et al. 2012) or HSPG2 and agrin (Hohenester & Yurchenko 2013) have been proposed as an alternative basis for the association of the laminin and collagen type IV networks in basement membrane. Nidogen-1 binds to the laminin-1 gamma subunit (Mayer et al. 1998). The gamma-2 chain of laminin-332 contains a homologous binding module. Nidogen-1 was reportedly unable to bind this laminin (Mayer et al. 1995), though an N-terminal fragment was able to bind (Sasaki et al. 2001). Laminin gamma-3 has been shown to bind to nidogen-1 and -2 with a lower affinity than that of gamma-1 (Gersdorff et al. 2005). The ab initio reconstruction of complexes between nidogen-1 and the laminin gamma-1 short arm confirms that this interaction is mediated solely by the C-terminal domains (Patel et al. 2013).

Participants
Participant Of
Inferred From
Authored
Reviewed
Created
Cite Us!