FN1 aggregation

Stable Identifier
R-HSA-2327746
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
Fibronectin aggregation
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The binding of integrins to each of the monomers in the FN1 dimer pair is thought to trigger a conformational change in FN1 that allows additional FN1 dimers to bind without pre-association with integrins (Singh et al. 2010). Domain I1-5 functions as the primary unit of FN1 matrix assembly (Sottile et al. 1991) but the process is not fully characterised and other FN1 units are likely to be involved (Singh et al. 2010). In this reaction an arbitrary 10 FN1 monomers are represented as being incorporated into the FN1 polymeric matrix.

Literature References
PubMed ID Title Journal Year
6643500 Fibronectin in extended and compact conformations. Electron microscopy and sedimentation analysis

Erickson, HP, Carrell, NA

J. Biol. Chem. 1983
20690820 Assembly of fibronectin extracellular matrix

Singh, P, Carraher, C, Schwarzbauer, JE

Annu. Rev. Cell Dev. Biol. 2010
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