FN1 aggregation

Stable Identifier
R-HSA-2327746
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Fibronectin aggregation
ReviewStatus
5/5
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FN1 aggregation
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The binding of integrins to each of the monomers in the FN1 dimer pair is thought to trigger a conformational change in FN1 that allows additional FN1 dimers to bind without pre-association with integrins (Singh et al. 2010). Domain I1-5 functions as the primary unit of FN1 matrix assembly (Sottile et al. 1991) but the process is not fully characterised and other FN1 units are likely to be involved (Singh et al. 2010). In this reaction an arbitrary 10 FN1 monomers are represented as being incorporated into the FN1 polymeric matrix.
Literature References
PubMed ID Title Journal Year
20690820 Assembly of fibronectin extracellular matrix

Singh, P, Schwarzbauer, JE, Carraher, C

Annu. Rev. Cell Dev. Biol. 2010
6643500 Fibronectin in extended and compact conformations. Electron microscopy and sedimentation analysis

Erickson, HP, Carrell, NA

J. Biol. Chem. 1983
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Orthologous Events
FN1 aggregation (Bos taurus)
FN1 aggregation (Caenorhabditis elegans)
FN1 aggregation (Canis familiaris)
FN1 aggregation (Mus musculus)
FN1 aggregation (Rattus norvegicus)
FN1 aggregation (Sus scrofa)
FN1 aggregation (Xenopus tropicalis)
Authored
Jupe, S  (2011-07-12)
Reviewed
Reinhardt, DP  (2013-02-08)
Created
Jupe, S  (2012-06-21)
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