Reactome | DDR1 binds collagen type I, II, III, IV, V, XI fibrils

DDR1 binds collagen type I, II, III, IV, V, XI fibrils

Stable Identifier

R-HSA-2327738

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

Synonyms

Discoidin domain receptor 1 binds collagens

ReviewStatus

5/5

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DDR1 binds collagen type I, II, III, IV, V, XI fibrils

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Discoidin domain receptors (DDRs) are a subfamily of receptor tyrosine kinases, the only members known to respond to an ECM component. DDR1 binds several of the major fibrillar collagens (types I, II, III, and V) and the non-fibrillar collagen IV (Shrivastava et al. 1997, Vogel et al. 1997, Hou et al. 2001). DDR proteins bind collagen as dimers (Leitinger 2003, 2011). DDR1 is mostly found in epithelial cells and leukocytes. It control developmental processes and regulates cell adhesion, migration, proliferation, and remodelling of the extracellular matrix by controlling the expression and activity of matrix metalloproteinases (Leitinger & Hohenester 2007).

Literature References

PubMed ID	Title	Journal	Year
9659900	An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors Shrivastava, A, Radziejewski, C, Campbell, E, Kovac, L, McGlynn, M, Ryan, TE, Davis, S, Goldfarb, MP, Glass, DJ, Lemke, G, Yancopoulos, GD	Mol. Cell	1997
9659899	The discoidin domain receptor tyrosine kinases are activated by collagen Vogel, W, Gish, GD, Alves, F, Pawson, T	Mol. Cell	1997