DDR1 binds collagen type I, II, III, IV, V, XI fibrils

Stable Identifier
Reaction [binding]
Homo sapiens
Discoidin domain receptor 1 binds collagens
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Discoidin domain receptors (DDRs) are a subfamily of receptor tyrosine kinases, the only members known to respond to an ECM component. DDR1 binds several of the major fibrillar collagens (types I, II, III, and V) and the non-fibrillar collagen IV (Shrivastava et al. 1997, Vogel et al. 1997, Hou et al. 2001). DDR proteins bind collagen as dimers (Leitinger 2003, 2011). DDR1 is mostly found in epithelial cells and leukocytes. It control developmental processes and regulates cell adhesion, migration, proliferation, and remodelling of the extracellular matrix by controlling the expression and activity of matrix metalloproteinases (Leitinger & Hohenester 2007).

Literature References
PubMed ID Title Journal Year
9659900 An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors

Campbell, E, Kovac, L, Glass, DJ, Lemke, G, Goldfarb, MP, Radziejewski, C, Yancopoulos, GD, Davis, S, Shrivastava, A, McGlynn, M, Ryan, TE

Mol. Cell 1997
9659899 The discoidin domain receptor tyrosine kinases are activated by collagen

Vogel, W, Gish, GD, Alves, F, Pawson, T

Mol. Cell 1997
Orthologous Events
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