The widely-expressed collagen receptors integrin alpha2beta1 and alpha1beta1 both bind collagen types I-IV (Tulla et al. 2001). Integrin alpha1beta1 binds to collagen type IV and VI with higher affinity than to types I-III, whereas alpha2beta1 has a higher affinity for collagen types I-III than for type IV (Tulla et al. 2001). Binding to collagen type I occurs at a site corresponding to residues 502-516 of the collagen alpha-1(I) chain (Knight et al. 1998, 2000, Xu et al. 2000). Integrin alpha2beta also binds collagen types VIII (Saelman et al. 1992), IX (Käpylä et al. 2004), XI (Tuckwell et al. 1995), the noncollagenous domain 1 (NC1) of collagen types VII and X (Chen et al. 1999), and collagen type XVI, though this is bound with higher affinity by integrin alpha1beta1 (Eble et al. 2006). Both integrins interactwith collagen XVI via the A-domain of their alpha-subunits. A tryptic fragment of collagen XVI comprising collagenous domains 1–3 is bound by integrin alpha1beta1. Electron microscopy of this complex or integrin alpha1beta1 with full-length collagen XVI revealed two unique integrin alpha1beta1 binding sites (GLQGER and GIKGER) within the N-terminal half of the COL2 domain of collagen XVI (Grässel & Bauer 2013).Integrin alpha1beta1 also binds collagen types IX (Käpylä et al. 2004), XVI (Eble et al. 2006), VIII though less strongly than alpha2 beta1 (Saelman et al. 1992), XIII (Nykvist et al. 2000) and arresten, the NC1 of alpha-1 type IV collagen (Sudhakar et al. 2005).Integrin alpha10beta1 is able to bind collagen types I-VI, with a stronger binding affinity for types IV and VI, similar to the preferences of integrin alpha1beta1 (Tulla et al. 2001). Integrin alpha11beta1 mediates cell adhesion to collagen types I and IV with a preference for I (Tiger et al. 2001). Integrins alphaVbeta3 (Sudhakar et al. 2003) and alpha3beta1 (Borza et al. 2006) can bind tumstatin, the cleaved NC1 of alpha-3 type IV collagen. Integrins alphaVbeta3 and alphavbeta5 can bind camstatin, the cleaved NC1 of alpha-2 type IV collagen (Magnon et al. 2005).
Nissinen, L, Jäälinoja, J, Heino, J, Vehviläinen, P, Farndale, RW, Viitasalo, T, Ala-Kokko, L, Marjomäki, V, Ylöstalo, J, Säämänen, AM, Nykvist, P, Tulla, M, Birk, DE, Käpylä, J
Niland, S, Kassner, A, Grässel, S, Mörgelin, M, Grifka, J, Eble, JA
Nieuwenhuis, HK, Williams, S, Gralnick, HR, Saelman, EU, McKeown, L, Sage, EH, Hese, KM, de Groot, PG, Sixma, JJ, Heijnen, HF
Kühn, K, Golbik, R, Eble, J, Kern, A
Nissinen, L, Nykvist, P, Johnson, MS, Impola, U, Viitasalo, T, Tulla, M, Pentikäinen, OT, Heino, J, Käpylä, J
© 2022 Reactome
