miR-26A microRNAs bind PTEN mRNA

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R-HSA-2318752
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Reaction [binding]
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Homo sapiens
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MIR26A microRNAs, miR-26A1 and miR-26A2, transcribed from genes on chromosome 3 and 12, respectively, bind PTEN mRNA (Huse et al. 2009).

The MIR26A2 locus is frequently amplified in glioma tumors that retain one wild-type PTEN allele. The resulting miR-26A2 overexpression leads to down-regulation of PTEN protein level. Overexpression of miR-26A2 was shown to enhance tumorigenesis and negatively correlates with the loss of heterozygosity at the PTEN locus in a mouse PTEN +/- glioma model, based on monoallelic PTEN loss (Huse et al. 2009, Kim et al. 2010).

Literature References
PubMed ID Title Journal Year
19487573 The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo

Huse, JT, Brennan, C, Hambardzumyan, D, Wee, B, Pena, J, Rouhanifard, SH, Sohn-Lee, C, le Sage, C, Agami, R, Tuschl, T, Holland, EC

Genes Dev. 2009
20080666 Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship

Kim, H, Huang, W, Jiang, X, Pennicooke, B, Park, PJ, Johnson, MD

Proc. Natl. Acad. Sci. U.S.A. 2010
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