AKT binds PDPK1

Stable Identifier
R-HSA-2317314
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
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Once phosphorylated on serine residue S473, AKT bound to PIP3 forms a complex with PIP3-bound PDPK1 i.e. PDK1 (Scheid et al. 2002, Sarabassov et al. 2005)

Literature References
PubMed ID Title Journal Year
12167717 Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

Scheid, MP, Marignani, PA, Woodgett, JR

Mol Cell Biol 2002
15718470 Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Sarbassov, DD, Guertin, DA, Ali, SM, Sabatini, DM

Science 2005
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed
Created