RALA:GTP binds MYO1C:CALM1 and activates MYO1C

Stable Identifier
R-HSA-2316349
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane, cytosol
ReviewStatus
5/5
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RALA:GTP binds MYO1C:CALM1 and activates MYO1C
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As inferred from mouse, insulin causes phosphorylation and inactivation of the Ral GTPase activating complex RGC, causing RALA:GTP to accumulate and associate with the unconventional myosin MYO1C. MYO1C, with calmodulin as a light chain, motors across cortical actin and interacts with the exocyst complex to tether vesicles at the plasma membrane (Chen et al. 2007).
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Output
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Inferred From
RalA:GTP binds Myo1c:Calm1 and F-actin (Mus musculus)
Authored
May, B  (2012-05-27)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2012-06-08)
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