Reactome | ASA- acetylates PTGS2

ASA- acetylates PTGS2

Stable Identifier

R-HSA-2314686

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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The ionized form of aspirin, acetylsalicylate (ASA-) reacts spontaneously with one subunit of PTGS2 dimer (Dong et al. 2011) to acetylate serine residue 516 (Lecomte et al. 1994). The modified enzyme is no longer capable of catalyzing the conversion of arachidonate to PGH2, but acquires the ability to convert it to 15R-HETE.

Literature References

PubMed ID	Title	Journal	Year
21467029	Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer Malkowski, MG, Vecchio, AJ, Jurban, BJ, Smith, WL, Sharma, NP, Dong, L	J. Biol. Chem.	2011
8175750	Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin Lecomte, M, DeWitt, DL, Smith, WL, Laneuville, O, Ji, C	J. Biol. Chem.	1994