Reactome | ASA- acetylates PTGS1

ASA- acetylates PTGS1

Stable Identifier

R-HSA-2314678

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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The ionized form of aspirin, acetylsalicylate (ASA-) reacts spontaneously with one subunit of PTGS1 dimer to acetylate serine residue 516. The modified enzyme is no longer capable of catalyzing the conversion of arachidonate to PGH2. The identity of the acetylated residue is inferred from data for the humann PTGS2 enzyme (Lecomte et al. 1994) and the ovine PGHS1 enzyme (Loll et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
8175750	Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin Lecomte, M, Laneuville, O, Ji, C, DeWitt, DL, Smith, WL	J. Biol. Chem.	1994
7552725	The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase Loll, PJ, Picot, D, Garavito, RM	Nat. Struct. Biol.	1995