PTGS2 dimer binds PTGS2 inhibitors

Stable Identifier
R-HSA-2309779
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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PTGS2 dimer binds PTGS2 inhibitors
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While closely similar, PTGS1 and 2 differ sufficiently in the structures of their active sites so that the latter enzyme selectively binds and is inhibited by PTGS2 inhibitors (benzquinamide, carprofen, celecoxib, etodolac, etoricoxib, lumiracoxib, rofecoxib, valdecoxib) (Luong et al. 1996; Smith et al. 2000; Dong et al. 2011).
Literature References
PubMed ID Title Journal Year
21467029 Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer

Malkowski, MG, Vecchio, AJ, Jurban, BJ, Smith, WL, Sharma, NP, Dong, L

J. Biol. Chem. 2011
10966456 Cyclooxygenases: structural, cellular, and molecular biology

DeWitt, DL, Smith, WL, Garavito, RM

Annu Rev Biochem 2000
8901870 Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

Browner, MF, Miller, A, Ramesha, C, Barnett, J, Chow, J, Luong, C

Nat. Struct. Biol. 1996
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Authored
D'Eustachio, P  (2012-06-06)
Reviewed
Rush, MG  (2012-11-10)
Created
D'Eustachio, P  (2012-06-06)
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