Reactome | PGG2 is reduced to PGH2 by PTGS2

PGG2 is reduced to PGH2 by PTGS2

Stable Identifier

R-HSA-2309773

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

Synonyms

Peroxidative reduction of PGG2 to PGH2

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Fatty acid metabolism (Homo sapiens)
    - Arachidonic acid metabolism (Homo sapiens)
      - Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Homo sapiens)
        
        PGG2 is reduced to PGH2 by PTGS2 (Homo sapiens)
- Metabolism of vitamins and cofactors (Homo sapiens)
  - Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
    - Nicotinate metabolism (Homo sapiens)
      - Nicotinamide salvaging (Homo sapiens)
        
        PGG2 is reduced to PGH2 by PTGS2 (Homo sapiens)

General

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Prostaglandin G/H synthase 2 (PTGS2) exhibits a dual catalytic activity, a cyclooxygenase and a peroxidase. The peroxidase function converts prostaglandin G2 (PGG2) to prostaglandin H2 (PGH2) via a two-electron reduction (Hamberg et al. 1973, Hla & Neilson 1992, Swinney et al. 1997, Barnett et al. 1994).

Literature References

PubMed ID	Title	Journal	Year
7947975	Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system Barnett, J, Chow, J, Ives, D, Chiou, M, Mackenzie, R, Osen, E, Nguyen, B, Tsing, S, Bach, C, Freire, J	Biochim Biophys Acta	1994
9139685	Differential allosteric regulation of prostaglandin H synthase 1 and 2 by arachidonic acid Swinney, DC, Mak, AY, Barnett, J, Ramesha, CS	J Biol Chem	1997
4514999	Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis Hamberg, M, Samuelsson, B	Proc Natl Acad Sci U S A	1973
1380156	Human cyclooxygenase-2 cDNA Hla, T, Neilson, K	Proc Natl Acad Sci U S A	1992