PGG2 is reduced to PGH2 by PTGS2

Stable Identifier
R-HSA-2309773
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
Synonyms
Peroxidative reduction of PGG2 to PGH2
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PGG2 is reduced to PGH2 by PTGS2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Prostaglandin G/H synthase 2 (PTGS2) exhibits a dual catalytic activity, a cyclooxygenase and a peroxidase. The peroxidase function converts prostaglandin G2 (PGG2) to prostaglandin H2 (PGH2) via a two-electron reduction (Hamberg et al. 1973, Hla & Neilson 1992, Swinney et al. 1997, Barnett et al. 1994).

Literature References
PubMed ID Title Journal Year
9139685 Differential allosteric regulation of prostaglandin H synthase 1 and 2 by arachidonic acid

Mak, AY, Ramesha, CS, Swinney, DC, Barnett, J

J Biol Chem 1997
7947975 Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system

Osen, E, Chow, J, Chiou, M, Mackenzie, R, Bach, C, Tsing, S, Freire, J, Ives, D, Barnett, J, Nguyen, B

Biochim Biophys Acta 1994
4514999 Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis

Hamberg, M, Samuelsson, B

Proc Natl Acad Sci U S A 1973
1380156 Human cyclooxygenase-2 cDNA

Hla, T, Neilson, K

Proc Natl Acad Sci U S A 1992
Participants
Input
Output
Participates
as an event of
Catalyst Activity

peroxidase activity of PTGS2 dimer [endoplasmic reticulum membrane]

Physical Entity
PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
Activity
peroxidase activity (GO:0004601)
This event is regulated
Negatively by
Regulator
PTGS2 dimer:PTGS2 inhibitors [endoplasmic reticulum membrane] (Homo sapiens)
Positively by
Regulator
MNA [cytosol]
Orthologous Events
PGG2 is reduced to PGH2 by PTGS2 (Bos taurus)
PGG2 is reduced to PGH2 by PTGS2 (Canis familiaris)
PGG2 is reduced to PGH2 by PTGS2 (Danio rerio)
PGG2 is reduced to PGH2 by PTGS2 (Gallus gallus)
PGG2 is reduced to PGH2 by PTGS2 (Mus musculus)
PGG2 is reduced to PGH2 by PTGS2 (Rattus norvegicus)
PGG2 is reduced to PGH2 by PTGS2 (Sus scrofa)
PGG2 is reduced to PGH2 by PTGS2 (Xenopus tropicalis)
Authored
Jassal, B  (2008-10-01)
Reviewed
Rush, MG  (2012-11-10)
Created
D'Eustachio, P  (2012-06-06)
Cite Us!