PGG2 is reduced to PGH2 by PTGS2

Stable Identifier
Reaction [transition]
Homo sapiens
Peroxidative reduction of PGG2 to PGH2
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Prostaglandin G/H synthase 2 (PTGS2) exhibits a dual catalytic activity, a cyclooxygenase and a peroxidase. The peroxidase function converts prostaglandin G2 (PGG2) to prostaglandin H2 (PGH2) via a two-electron reduction (Hamberg et al. 1973, Hla & Neilson 1992, Swinney et al. 1997, Barnett et al. 1994).

Literature References
PubMed ID Title Journal Year
7947975 Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system

Barnett, J, Chow, J, Ives, D, Chiou, M, Mackenzie, R, Osen, E, Nguyen, B, Tsing, S, Bach, C, Freire, J

Biochim Biophys Acta 1994
9139685 Differential allosteric regulation of prostaglandin H synthase 1 and 2 by arachidonic acid

Swinney, DC, Mak, AY, Barnett, J, Ramesha, CS

J Biol Chem 1997
4514999 Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis

Hamberg, M, Samuelsson, B

Proc Natl Acad Sci U S A 1973
1380156 Human cyclooxygenase-2 cDNA

Hla, T, Neilson, K

Proc Natl Acad Sci U S A 1992
Participant Of
Catalyst Activity
Catalyst Activity
peroxidase activity of PTGS2 dimer [endoplasmic reticulum membrane]
Physical Entity
This event is regulated
Positively by
Orthologous Events