PGG2 is reduced to PGH2 by PTGS2

Stable Identifier
R-HSA-2309773
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Peroxidative reduction of PGG2 to PGH2
ReviewStatus
5/5
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Prostaglandin G/H synthase 2 (PTGS2) exhibits a dual catalytic activity, a cyclooxygenase and a peroxidase. The peroxidase function converts prostaglandin G2 (PGG2) to prostaglandin H2 (PGH2) via a two-electron reduction (Hamberg et al. 1973, Hla & Neilson 1992, Swinney et al. 1997, Barnett et al. 1994).
Literature References
PubMed ID Title Journal Year
9139685 Differential allosteric regulation of prostaglandin H synthase 1 and 2 by arachidonic acid

Mak, AY, Ramesha, CS, Swinney, DC, Barnett, J

J Biol Chem 1997
7947975 Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system

Osen, E, Chow, J, Chiou, M, Mackenzie, R, Bach, C, Tsing, S, Freire, J, Ives, D, Barnett, J, Nguyen, B

Biochim Biophys Acta 1994
4514999 Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis

Hamberg, M, Samuelsson, B

Proc Natl Acad Sci U S A 1973
1380156 Human cyclooxygenase-2 cDNA

Hla, T, Neilson, K

Proc Natl Acad Sci U S A 1992
Participants
Participates
Catalyst Activity

peroxidase activity of PTGS2 dimer [endoplasmic reticulum membrane]

This event is regulated
Positively by
Regulator
Orthologous Events
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