Prostaglandin G/H synthase 2 (PTGS2) exhibits a dual catalytic activity, a cyclooxygenase and a peroxidase. The peroxidase function converts prostaglandin G2 (PGG2) to prostaglandin H2 (PGH2) via a two-electron reduction (Hamberg et al. 1973, Hla & Neilson 1992, Swinney et al. 1997, Barnett et al. 1994).
Mak, AY, Ramesha, CS, Swinney, DC, Barnett, J
Osen, E, Chow, J, Chiou, M, Mackenzie, R, Bach, C, Tsing, S, Freire, J, Ives, D, Barnett, J, Nguyen, B
Hamberg, M, Samuelsson, B
Hla, T, Neilson, K
peroxidase activity of PTGS2 dimer [endoplasmic reticulum membrane]
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